Results 31 to 40 of about 115,986 (250)

The gut microbiota and developmental programming of the testis in mice.

PLoS ONE, 2014
Nutrients and environmental chemicals, including endocrine disruptors, have been incriminated in the current increase in male reproductive dysfunction, but the underlying mechanisms remain unknown.
Maha Al-Asmakh, Jan-Bernd Stukenborg, Ahmed Reda, Farhana Anuar, Mona-Lisa Strand, Lars Hedin, Sven Pettersson, Olle Söder   +7 more
doaj   +1 more source

Induction of temporary otitis media in specific-pathogen-free pigs by intratympanic inoculation of Mycoplasma hyorhinis.

American Journal of Veterinary Research, 1998
OBJECTIVE To examine whether Mycoplasma hyorhinis inoculated into the tympanic cavity can cause otitis media in pigs. ANIMALS 17- or 22-day-old specific-pathogen-free pigs.
T. Morita, Aya Sasaki, N. Kaji, Akinori Shimada, S. Kazama, Takeshi Yagihashi, Takashi Umemura   +6 more
semanticscholar   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Profiling microbial strains in urban environments using metagenomic sequencing data

Biology Direct, 2018
Background The microbial communities populating human and natural environments have been extensively characterized with shotgun metagenomics, which provides an in-depth representation of the microbial diversity within a sample. Microbes thriving in urban
Moreno Zolfo, Francesco Asnicar, Paolo Manghi, Edoardo Pasolli, Adrian Tett, Nicola Segata   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A comparison of the antibody responses between specific pathogen-free and commercial layers immunized with an influenza vaccine prepared from inactivated non-pathogenic H5N1 virus by single shot.

Journal of Veterinary Medical Science, 2010
It is known that antibody responses in chickens against invading organisms or antigens are considerably different among different lines. Thus, an avian influenza vaccine was prepared from inactivated whole particles of the virus of non-pathogenic strain ...
Takashi Sasaki, N. Kokumai, T. Ohgitani, T. Imamura, A. Sawata, Zhifeng Lin, Y. Sakoda, H. Kida   +7 more
semanticscholar   +1 more source

The Pathogenic Effects of Moroccan Very Virulent Infectious Bursal Disease Virus on Lymphoid Organs: A Comparative Study in Conventional Broiler and Specific-Pathogen-Free Chickens

Veterinary Sciences
Infectious bursal disease (IBD) is a major immunosuppressive disease affecting young chickens, and causes significant economic losses to the poultry industry. This work represents the first pathogenicity assessment of Moroccan very virulent IBD virus.
Charifa Drissi Touzani, Imane Maaroufi, Ikhlass El Berbri, Fatima-Zohra Sikht, Ouafaa Fassi Fihri, Noursaid Tligui, Mohammed El Houadfi, Siham Fellahi   +7 more
openaire   +3 more sources

Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE) randomised clinical trial: study protocol

BMJ Open, 2020
Introduction Bloodstream infections are a leading cause of mortality and morbidity; the duration of treatment for these infections is understudied.Methods and analysis We will conduct an international, multicentre randomised clinical trial of shorter (7 ...
Nick Daneman, Deborah J Cook, Richard Hall, John Muscedere, Yaseen M Arabi, Rachael Parke, Steven Reynolds, Asgar H Rishu, Ruxandra L Pinto, Shay McGuinness, Benjamin Rogers, Yahya Shehabi, Robert A Fowler   +12 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source