Results 131 to 140 of about 4,456,677 (340)

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

open access: yesFEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li   +3 more
wiley   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

open access: yesFEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield   +3 more
wiley   +1 more source

Generality, Specificity And Discovery [PDF]

open access: yes
This paper offers a meta-theory concerning the relation between the general and the specific in science. This issue was recently called back to attention by Hodgson (2001). A heuristic of discovery, developed in earlier work (Nooteboom 1992, 1996, 1999b,
Nooteboom, B.
core   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

open access: yesFEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász   +6 more
wiley   +1 more source

Input Specificity and Location [PDF]

open access: yes
In a two-region economy, two upstream firms supply an input to two consumer goods firms. For two different location patterns (site specificity and co-location of the suppliers), the firms play a three-stage game: the input suppliers select transport ...
Jose Pedro Pontes
core  

Interspecies reactivity and intraspecies specificity of antilymphoid globulin [PDF]

open access: yes, 1967
Horse antihuman and antidog antilymphocyte globulins were shown to possess leukoagglutinating antibodies when tested against the white cells from a number of other divergent species.
Iwasaki, Y   +5 more
core  

Substrate Specificity of Peptide Adsorption: A Model Study

open access: yes, 2007
Applying the contact density chain-growth algorithm to lattice heteropolymers, we identify the conformational transitions of a nongrafted hydrophobic-polar heteropolymer with 103 residues in the vicinity of a polar, a hydrophobic, and a uniformly ...
L. Toma   +2 more
core   +1 more source

ON SPECIFIC NAMES [PDF]

open access: yesThe Canadian Entomologist, 1889
Dr. Williston, in his painstaking work on the Syrphidœ says: “There are no generic and specific limitations in nature”, and illustrates the statement by the present knowledge of the family with which his synopsis deals. And what Dr. Williston brings forward is a mere quota of the mass of evidence brought out by natrualists generally, and entomologists ...
openaire   +2 more sources

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