Results 231 to 240 of about 4,678,205 (343)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Load-Carriage Conditioning Elicits Task-Specific Physical and Psychophysical Improvements in Males

, 2019
Jodie A. Wills, David J. Saxby, Daniel J. Glassbrook, Tim L. A. Doyle   +3 more
openalex   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Diagnostic Performance of a DOAC Urine Dipstick in Obese Outpatients with Atrial Fibrillation: Comparison with Plasma Concentrations. [PDF]

J Clin Med
Pannunzio A, Castellani V, Baldacci E, Cammisotto V, Mormile R, Palumbo IM, Porcu N, Chistolini A, Bernardini G, Menichelli D, Pastori D, Harenberg J, Violi F, Pignatelli P.   +13 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The Cut-Off Values for SHBG Discriminating Insulin Resistance Based on the TyG, TyG-BMI, and TyG-WC Values in Women with PCOS. [PDF]

Biomedicines
Kochanowicz M, Rhaiem TB, Owczarek AJ, Wójtowicz M, Madej P, Chudek JT, Olszanecka-Glinianowicz M.   +6 more
europepmc   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Structured interconnectivity optimizes neural geometry for balancing specificity and generalization in object recognition. [PDF]

Commun Biol
Zhang Y, Liu J, Liu J.
europepmc   +1 more source

Application of Thesaurus for the Identification of the Specific Situations [PDF]

, 2018
Natalia Pavlovna Tuchkova, Alexander Muromskij   +1 more
openalex   +1 more source

Context effects in bilingual sentence processing : task specificity [PDF]

, 2016
A Caramazza, A Costa, AB Arêas Da Luz Fontes, AI Schwartz, AI Schwartz, AL Dunn, AMB Groot De, AMB Groot De, B New, CM Brown, D Gentner, D Jared, D Titone, DW Green, E Assche Van, E Assche Van, E Assche Van, E Assche Van, E Keuleers, F Cuetos, GC Orden Van, J Altarriba, J Segui, JG Hell Van, JG Hell Van, K Baten, K Lemhöfer, K Lemhöfer, K Rayner, K Rayner, K Rayner, KE Elston-Güttler, KE Stanovich, LAURA WINTHER BALLING, M Brysbaert, M Coltheart, MA Just, MR Libben, PJ Schwanenflugel, Q Cai, RM Sánchez-Casas, S Bentin, SA Duffy, T Degani, T Dijkstra, T Dijkstra, T Dijkstra, T Dijkstra, T Dijkstra, T Dijkstra, V Marian, VI Levenshtein, W Duyck, W Duyck   +53 more
core   +1 more source