Results 111 to 120 of about 237,317 (388)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Unassisted Quantitative Evaluation Of Despeckling Filters

, 2017
SAR (Synthetic Aperture Radar) imaging plays a central role in Remote Sensing due to, among other important features, its ability to provide high-resolution, day-and-night and almost weather-independent images.
Frery, Alejandro C., Gomez, Luis, Ospina, Raydonal   +2 more
core   +1 more source

Speckle noise reduction techniques for high-dynamic range imaging [PDF]

, 2007
High-dynamic range imaging from space in the visible, aiming in particular at the detection of terrestrial exoplanets, necessitates not only the use of a coronagraph, but also of adaptive optics to correct optical defects in real time.
Belikov, Belikov, Bordé, Bordé, Bordé, Codona, Dohlen, Give'on, Guyon, Guyon, Guyon, Kasdin, Kuchner, Lyot, Malbet, Pascal Bordé, Putnam, Roddier, Rouan, Shaklan, Traub, Trauger, Trauger, Wesley Traub   +23 more
core   +3 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Statistical Properties of an Unassisted Image Quality Index for SAR Imagery

Remote Sensing, 2019
The M estimator is a recently proposed image-quality index used to evaluate the despeckling operation in SAR (Synthetic Aperture Radar) data. It is used also to rank despeckling filters and to improve their design.
Luis Gomez, Raydonal Ospina, Alejandro C. Frery   +2 more
doaj   +1 more source

Harnessing speckle for a sub-femtometre resolved broadband wavemeter and laser stabilization [PDF]

Nature Communications, 2017
The accurate determination and control of the wavelength of light is fundamental to many fields of science. Speckle patterns resulting from the interference of multiple reflections in disordered media are well-known to scramble the information content of
N. K. Metzger, R. Spesyvtsev, G. Bruce, B. Miller, G. Maker, G. Malcolm, M. Mazilu, K. Dholakia   +7 more
semanticscholar   +1 more source

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini, Paolo Preziosa, Paola Valsasina, Damiano Mistri, Monica Margoni, Federica Esposito, Massimo Filippi, Maria A. Rocca   +7 more
wiley   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Choosing a laser for laser speckle contrast imaging

Scientific Reports, 2019
The use of laser speckle contrast imaging (LSCI) has expanded rapidly for characterizing the motion of scattering particles. Speckle contrast is related to the dynamics of the scattering particles via a temporal autocorrelation function, but the quality ...
D. Postnov, Xiaojun Cheng, Ş. E. Erdener, D. Boas   +3 more
semanticscholar   +1 more source