Results 91 to 100 of about 2,300,127 (311)
THE TOHOKU TSUNAMI OF 11 MARCH 2011 AS RECORDED ON THE RUSSIAN FAR EAST [PDF]
Science of Tsunami Hazards, 2012 The source region of the catastrophic Tohoku tsunami of 11 March 2011 was near the Russian Far East, thus a warning was issued for threatened coasts of the Kuril Islands and Kamchatka.
G. V. Shevchenko, T. N. Ivelskaya
doaj
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The spectra and fine spectra of factorable matrices on $c_0$
Mathematical Communications, 2011 In a series of papers we have previously investigated the spectra and fine spectra for factorable matrices, considered as bounded operators over various sequence spaces. In this paper we examine the spectra and fine spectra of factorable matrices as operators over $c_0$, the space of all null sequences, normed by $\|x\| := \sup_{n\geq 0}|x_n|$.
Rhoades B.E., Yildirim M.
openaire +6 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Function spectra and continuous G -spectra [PDF]
Bulletin of the London Mathematical Society, 2011 Let G be a profinite group, {X_alpha}_alpha a cofiltered diagram of discrete G-spectra, and Z a spectrum with trivial G-action. We show how to define the homotopy fixed point spectrum F(Z, holim_alpha X_alpha)^{hG} and that when G has finite virtual cohomological dimension (vcd), it is equivalent to F(Z, holim_alpha (X_alpha)^{hG}).
openaire +2 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source