Results 81 to 90 of about 918,355 (267)
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
The present study is a theoretical investigation into the structural evolution, electronic properties, and photoelectron spectra of phosphorus-doped boron clusters PBn0/− (n = 3–17). The results of this study revealed that the lowest energy structures of
Danyu Wang +3 more
doaj +1 more source
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +1 more source
The spectra and fine spectra of factorable matrices on $c_0$
In a series of papers we have previously investigated the spectra and fine spectra for factorable matrices, considered as bounded operators over various sequence spaces. In this paper we examine the spectra and fine spectra of factorable matrices as operators over $c_0$, the space of all null sequences, normed by $\|x\| := \sup_{n\geq 0}|x_n|$.
Rhoades B.E., Yildirim M.
openaire +6 more sources
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Thom spectra that are symmetric spectra
We analyze the functorial and multiplicative properties of the Thom spectrum functor in the setting of symmetric spectra and we establish the relevant homotopy invariance.
openaire +3 more sources
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
The Spectra and the Duration of Low Vowels in Standard Lithuanian and Latvian
This article analyses the quantity and quality features of the stressed and unstressed short and long low vowel phonemes [a] and [e] in Standard Lithuanian and Latvian, focussing on Lithuanian and Latvian trisyllabic words.
Lidija Kaukėnienė
doaj +1 more source

