Results 111 to 120 of about 96,121 (306)

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Convolution operators and the discrete Laplacian

, 2009
PhDIn this thesis, we obtain new results for convolution operators on homogeneous spaces and give applications to the Laplacian on a homogeneous graph. Some of these results have been published in joint papers [13, 14] with my supervisor.
Chen, Chung-Chuan
core  

The adjacency spectrum of two new operations of graphs

AKCE International Journal of Graphs and Combinatorics, 2018
Let be a graph and be its adjacency matrix. The eigenvalues of are the eigenvalues of and form the adjacency spectrum, denoted by . In this paper, we introduce two new operations and , and describe the adjacency spectra of and of regular graphs , and ...
Dijian Wang, Yaoping Hou, Zikai Tang
doaj   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Symmetric graphs - spectra and eigenvectors [PDF]

, 2012
2nd revised Edition.Davidson (1981) developed a general procedure, based on group representation theory, for determining the spectra of graphs distinguished by a certain rotational symmetry, with application to molecular graphs.
Sachs, Horst, John, Peter E.
core  

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Adjacency spectral characterization of the graph

, 2020
In A.Z. Abdian, Two classes of multicone graphs determinedby their spectra, J. Math. Ext.,10(2016), 111–121, it was conjectured thatthe complement of the multicone graphs, the join of a clique and a regulargraph,Kw5P17andKw5S, are determined by ...
Reza Sharafdin; iDepartment of Mathematics, Persian Gulf University, Bushehr 75169-13817, Iran, Sara Pouyandeh; Department of Mathematics, Payame Noor University, Tehran 19395-3697, Ali Zeydi Abdian; College of Science, Lorestan University, Lorestan, Khoramabad, Iran   +2 more
core  

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Graph-Theoretic Limits of Distributed Computation: Entropy, Eigenvalues, and Chromatic Numbers

Entropy
We address the problem of the distributed computation of arbitrary functions of two correlated sources, X1 and X2, residing in two distributed source nodes, respectively.
Mohammad Reza Deylam Salehi, Derya Malak
doaj   +1 more source