Results 111 to 120 of about 1,846,403 (331)

Mesh Update Techniques for Free-Surface Flow Solvers Using Spectral Element Method [PDF]

, 2018
This paper presents a novel mesh-update technique for unsteady free-surface Newtonian flows using spectral element method and relying on the arbitrary Lagrangian-Eulerian kinematic description for moving the grid.
Bouffanais, Roland, Deville, Michel
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Forced vibration assessment of moderately thick carbon nanotube-reinforced composite plates

Results in Physics
Carbon nanotubes, distributed in composite sheets with various arrangements, can lead to the development of materials with functionally graded properties.
Reza Setayesh, Shahabeddin Hatami, Mojtaba Gorji Azandariani, Mohammad Zamani Nejad   +3 more
doaj   +1 more source

Multi-solver spectral-element and adjoint methods

, 2020
The spectral-element method (SEM) for simulating wave propagation is widely used with adjoint methods for full-waveform inversion.
Yujiang Xie, Catherine A. Rychert, Nicholas Harmon, Qinya Liu, Dirk Gajewski   +4 more
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

On the solution of boundary value problems by the spectral element method

Қарағанды университетінің хабаршысы. Математика сериясы, 2015
In spectral element method approximate solution of the original differential operator is found in the form of a combination of the linearly independent system of orthogonal functions on the unit interval.
I.A. Ivanov, A.N. Yesbayev, G.A. Yessenbayeva, M.I. Ramazanov   +3 more
doaj  

DISCONTINUOUS GALERKIN SPECTRAL ELEMENT METHOD TO COMPUTE REFLECTION AND TRANSMISSION OF ELECTROMAGNETIC WAVES

Revista de Matemática: Teoría y Aplicaciones, 2018
Modeling wave reflection and transmission is important for a diversity of applications in physics and engineering. Examples can be found in acoustics and electromagnetism. Computational wave propagation requires high order accuracy both in space and time
MÓNICA MESA MAZO, CÉSAR ACOSTA MINOLI, HERNÁN TORO ZAPATA   +2 more
doaj   +1 more source

Nonlinear artificial viscosity for spectral element methods

Comptes Rendus. Mathématique, 2019
We present a filter-based approach to computing artificial viscosities for spectral element methods. A number of applications for this approach are presented.
Lu, Li, Nazarov, Murtazo, Fischer, Paul
openaire   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source