Results 111 to 120 of about 6,363,211 (303)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Influence of base impurity distribution on the photoelectric properties of surface-barrier UV photodetectors

Технологія та конструювання в електронній апаратурі, 2012
The article presents the study on spectral, capacitance-voltage and current-voltage characteristics of surface-barrier structures based on A2B6 composition with different carrier concentration profiles in space-charge region sensitive to ultraviolet ...
Yu. N. Bobrenko, V. N. Komaschenko, N. V. Yaroshenko, G. I. Sheremetova, B. S. Atdaev   +4 more
doaj  

Satellite Monitoring of Sayan Mountain Forest Ecosystems [PDF]

Журнал Сибирского федерального университета: Серия Биология, 2011
New approach to use remote sensing data of low and moderate spatial resolution is suggested for forest cover mapping and for its seasonal monitoring. The researches of forest structure and dynamics are conducted on three test sites of the Western and ...
Evgeny I. Ponomarev, Dilshad M. Ismailova, Dina I. Nazimova   +2 more
doaj  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Investigations of spectral peaks, resonance effect and 1/f exponents on noise characteristics of MEMS accelerometers

, 2004
Further investigations of the noise characteristics of MEMS accelerometers at different accelerations are presented. In the previously published work, the results show 1/f-type noise at low frequencies and white noise at high frequencies.
Nagel, D, Chuah, H, Korman, C, Mohd-Yasin, F   +3 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Research on Non Destructive Detection Method and Model Op-Timization of Nitrogen in Facility Lettuce Based on THz and NIR Hyperspectral

Agronomy
Considering the growing demand for modern facility agriculture, it is essential to develop non-destructive technologies for assessing lettuce nutritional status. To overcome the limitations of traditional methods, which are destructive and time-consuming,
Yixue Zhang, Jialiang Zheng, Jingbo Zhi, Jili Guo, Jin Hu, Wei Liu, Tiezhu Li, Xiaodong Zhang   +7 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

On-Line Component Analysis of Cement Powder Using LIBS Technology

, 2019
In the process of cement production in the industrial field, the content of each component in the cement directly affects the quality of the cement. Therefore, it is of great significance to quickly and accurately monitor the content of each component in
Sun Lan-xiang, Qi Li-feng, Zeng Peng, Shi You-zhen, Zhou Zhong-han, Zhang Peng, Guo Zhi-wei, Wang Wei, Yu Hai-bin   +8 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source