Results 81 to 90 of about 6,363,211 (303)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

davemlz/spectral: 0.0.5

open access: yes, 2021
Spectral v0.0.5 :artificial_satellite: :seedling: New Features The omega parameter was added to defaultParameters and describeParameters. The lambdaN, lambdaR and lambdaG parameters were added to describeParameters. The k was added to describeParameters.
David Montero Loaiza
core   +1 more source

A Classification Method of Earthquake Ground Motion Records Based on the Results of K-Means Clustering Analysis

open access: yesBuildings
This paper presents a classification method for earthquake ground motion records utilizing the results of K-means cluster analysis. The moment magnitude and Joyner–Boore distance are utilized as the primary parameters for clustering the earthquake ground
Yanqiong Ding   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

On Some Distance Spectral Characteristics of Trees

open access: yesAxioms
Graham and Pollack in 1971 presented applications of eigenvalues of the distance matrix in addressing problems in data communication systems. Spectral graph theory employs tools from linear algebra to retrieve the properties of a graph from the spectrum of graph-theoretic matrices. The study of graphs with “few eigenvalues” is a contemporary problem in
Sakander Hayat   +2 more
openaire   +2 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Development of a methodology for assessment of contaminated territories based on the utilization of direct spectral probing with the implementation of state indices

open access: yesRUDN Journal of Ecology and Life Safety
The study describes the process of survey of contaminated territories using contact spectral sounding. The main stages of the survey are considered, including preparation for work, data collection, their processing and analysis, as well as interpretation
Tatyana V. Berdnikova
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

Estimating spectral irradiance from measurements in seven spectral bands

open access: yes, 2003
Accurate measurement and characterisation of fluctuations in the irradiance environment is important for many areas of optical remote sensing. This paper reports a method of estimating spectral irradiance over the VNIR region (400 - 1100nm) from the ...
Milton, E.J., Rollin, E.M.
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

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