Results 101 to 110 of about 1,461,923 (295)
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Directional clustering through matrix factorization [PDF]
, 2016 This paper deals with a clustering problem where feature vectors are clustered depending on the angle between feature vectors, that is, feature vectors are grouped together if they point roughly in the same direction.
Blumensath, Thomas
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Spectral Clustering for Graphs and Markov Chains
, 2010 Spectral graph partitioning based on spectral theory has become a popular clustering method over the last few years. The starting point is the work of Fiedler who shows that an eigenvector of the Laplacian matrix of an undirected graph (symmetric system)
Liu, Ning
core
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
, 2009 In this paper, we propose a new spectral clustering method, referred to as Spectral Embedded Clustering (SEC), to minimize the normalized cut criterion in spectral clustering as well as control the mismatch between the cluster assignment matrix and the ...
Zhang, Changshui +3 more
core +1 more source
A topological approach to spectral clustering
Foundations of Data Science, 2021 We propose two related unsupervised clustering algorithms which, for input, take data assumed to be sampled from a uniform distribution supported on a metric space $X$, and output a clustering of the data based on the selection of a topological model for the connected components of $X$.
openaire +4 more sources
MACOC: a medoid-based ACO clustering algorithm [PDF]
, 2014 The application of ACO-based algorithms in data mining is growing over the last few years and several supervised and unsupervised learning algorithms have been developed using this bio-inspired approach. Most recent works concerning unsupervised learning
Otero, Fernando E. B. +7 more
core +1 more source