Results 111 to 120 of about 74,563 (305)

Spectral Clustering of Psychological Networks

open access: yes, 2021
Spectral clustering is a well-known method for clustering the vertices of an undirected network. Although its use in network psychometrics has been limited, spectral clustering has a close relationship to the commonly-used walktrap algorithm.
Douglas Steinley   +2 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Outlier Cluster Formation in Spectral Clustering

open access: yesCoRR, 2017
10 pages, 2 figures, 2 ...
Takuro Ina   +5 more
openaire   +2 more sources

Spectral Representation for Matching and Recognition [PDF]

open access: yes, 2013
In this thesis, we aim to use the spectral graph theory to develop a framework to solve the problems of computer vision. The graph spectral methods are concerned with using the eigenvalues and eigenvectors of the adjacency matrix or closely related ...
Haseeb, Muhammad
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

A topological approach to spectral clustering

open access: yesFoundations of Data Science, 2021
We propose two related unsupervised clustering algorithms which, for input, take data assumed to be sampled from a uniform distribution supported on a metric space $X$, and output a clustering of the data based on the selection of a topological model for the connected components of $X$.
openaire   +4 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Clustering Affine Subspaces: Algorithms and Hardness [PDF]

open access: yes, 2012
We study a generalization of the famous k-center problem where each object is an affine subspace of dimension Δ, and give either the first or significantly improved algorithms and hardness results for many combinations of parameters.
Lee, Euiwoong
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

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