Results 161 to 170 of about 74,563 (305)

Efficacy of Inebilizumab in N‐MOmentum Trial Participants With or Without Prior Immunosuppressants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This post hoc analysis examined the impact of prior immunosuppressants on the long‐term efficacy and safety of inebilizumab, a cluster of differentiation 19+ B‐cell–depleting monoclonal antibody, in participants with aquaporin‐4–seropositive neuromyelitis optica spectrum disorder from the N‐MOmentum trial (NTC02200770).
Bruce A. C. Cree, Beatrice Suero, Sarah Walsh, Romain Marignier, John W. Lindsey, Ho Jin Kim, Dewei She, Daniel Cimbora, Dustin Cavida, Friedemann Paul   +9 more
wiley   +1 more source

Graph Convolutional Spectral Clustering for Electricity Market Data Clustering

Applied Sciences
As the power grid undergoes transformation and the Internet’s influence grows, the electricity market is evolving towards informatization. The expanding scale of the power grid and the increasing complexity of operating conditions have generated a ...
Longda Huang, Maohua Shan, Liguo Weng, Lingyi Meng   +3 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

Modelling and application of a spectral clustering method for shared bicycle trajectories

Geocarto International
Geographic flow clustering analysis can effectively reveal human behavioral patterns in movement. Traditional methods for studying human movement patterns are mostly based on first-order quantity analyses of point data, such as hotspots, density or ...
Wenwen Xing, Youjun Tu, Yuxing Gao, Zongyi He, Junli Li   +4 more
doaj   +1 more source

Noise Thresholds for Spectral Clustering

, 2018
Although spectral clustering has enjoyed considerable empirical success in machine learning, its theoretical properties are not yet fully developed. We analyze the performance of a spectral algorithm for hierarchical clustering and show that on a class ...
Aarti Singh (5358575), Min Xu (4502323), Akshay Krishnamurthy (5363951), Sivaraman Balakrishnan (5363903)   +3 more
core   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Cloud-Assisted Privacy-Preserving Spectral Clustering Algorithm Within a Multi-User Setting

IEEE Access
Spectral clustering, a powerful algorithm in the field of AI, holds a significant role despite its inherent high time complexity. For data owners grappling with limitations such as small datasets and restricted computational resources, harnessing the ...
Lida Xu, Xiangguo Cheng, Weizhong Tian, Huanli Wang, Yan Zhang   +4 more
doaj   +1 more source

Estimating Mixed Memberships in Directed Networks by Spectral Clustering. [PDF]

Entropy (Basel), 2023
Qing H.
europepmc   +1 more source