Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Mass Spectral Data of Primary and Secondary Metabolites Changes in Medicinal Plants by Solvent Polarity. [PDF]
Park J +7 more
europepmc +1 more source
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Empirical modelling of suspended sediments using spectral data from spectroradiometer and sentinel-2 in Mula Dam Reservoir, Maharashtra, India. [PDF]
Joshi JK +6 more
europepmc +1 more source
Rapid detection of sunset yellow adulteration in tea powder with variable selection coupled to machine learning tools using spectral data. [PDF]
Amsaraj R, Mutturi S.
europepmc +1 more source
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye +11 more
wiley +1 more source
ToF-SIMS spectral data analysis of <i>Paenibacillus sp.</i> 300A biofilms and planktonic cells. [PDF]
Parker GD, Plymale A, Hanley L, Yu XY.
europepmc +1 more source
Dataset containing spectral data from hyperspectral imaging and sugar content measurements of grapes berries in various maturity stage. [PDF]
Ryckewaert M +8 more
europepmc +1 more source
Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito +14 more
wiley +1 more source
Machine-Learning Approach to Identify Organic Functional Groups from FT-IR and NMR Spectral Data. [PDF]
Lee G, Shim H, Cho J, Choi SI.
europepmc +1 more source

