Results 101 to 110 of about 237,467 (314)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Signal Processing and Machine Learning as a Tool for Identifying Idling Noises of Different Circular Saw Blades

open access: yesBioResources
This study examines the possible utilization of machine learning and decision-making in the woodworking sector. This refers to the recognition of certain sounds produced during tool idling.
Mira Miric-Milosavljevic   +5 more
doaj   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

University proceedings. Volga region. Technical sciences

open access: yesИзвестия высших учебных заведений. Поволжский регион:Технические науки
Background. One of the dominant factors affecting the macro- and microgeometric accuracy parameters of parts is the dynamic quality of automated metal-cutting machines.
A.A. Ignatiev   +2 more
doaj   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

open access: yesMolecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa   +14 more
wiley   +1 more source

Spectral density-based clustering algorithms for complex networks. [PDF]

open access: yesFront Neurosci, 2023
Ramos TC, Mourão-Miranda J, Fujita A.
europepmc   +1 more source

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