Results 111 to 120 of about 5,734,459 (326)

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Normal Mode Analysis of the Spectral Density of the Fenna–Matthews–Olson Light-Harvesting Protein: How the Protein Dissipates the Excess Energy of Excitons

Journal of Physical Chemistry B, 2012
We report a method for the structure-based calculation of the spectral density of the pigment–protein coupling in light-harvesting complexes that combines normal-mode analysis with the charge density coupling (CDC) and transition charge from ...
T. Renger, Alexander Klinger, Florian Steinecker, Marcel Schmidt am Busch, J. Numata, F. Müh   +5 more
semanticscholar   +1 more source

Native ultrametricity of sparse random ensembles

, 2015
We investigate the eigenvalue density in ensembles of large sparse Bernoulli random matrices. We demonstrate that the fraction of linear subgraphs just below the percolation threshold is about 95\% of all finite subgraphs, and the distribution of linear ...
Avetisov, V., Krapivsky, P. L., Nechaev, S.   +2 more
core   +2 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Spectral density classification for environment spectroscopy

Machine Learning: Science and Technology
Spectral densities encode the relevant information characterizing the system–environment interaction in an open-quantum system problem. Such information is key to determining the system’s dynamics.
J Barr, G Zicari, A Ferraro, M Paternostro   +3 more
doaj   +1 more source

Properties of the phi meson at high temperatures and densities

, 2008
We calculate the spectral density of the phi meson in a hot bath of nucleons and pions using a general formalism relating self-energy to the forward scattering amplitude (FSA).
A. T. Martell, C. Gale, G. Vujanovic, J. I. Kapusta, J. Ruppert, V. L. Eletsky, W.-M. Yao   +6 more
core   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Neutrino spectral density at electroweak scale temperature

, 2013
Motivated by the scenario of resonant leptogenesis in which lepton number creation in the electroweak-scale is relevant, we investigate the spectral properties and possible collective nature of the standard model neutrinos at electroweak scale ...
Hidaka, Yoshimasa, Kunihiro, Teiji, Miura, Kohtaroh, Satow, Daisuke   +3 more
core   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Perturbations of diagonal matrices by band random matrices [PDF]

, 2011
We exhibit an explicit formula for the spectral density of a (large) random matrix which is a diagonal matrix whose spectral density converges, perturbated by the addition of a symmetric matrix with Gaussian entries and a given (small) limiting variance ...
Benaych-Georges, Florent, Enriquez, Nathanaël   +1 more
core   +3 more sources