Results 41 to 50 of about 653,662 (247)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

On the spectral efficiency of a sphere [PDF]

, 2004
In many cases it is desired to have both high capacity and small antennas in wireless communication systems. Unfortunately, the antenna performance deteriorate when the antennas get electrically small. In this paper fundamental limitations from antenna theory and broadband matching are used to analyze the spectral eciency of an arbitrary antenna ...
Gustafsson, Mats, Nordebo, Sven
openaire   +1 more source

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

Molecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens, Anouk Mentink, Frank A. W. Coumans, Eshwari Dathathri, Khrystany T. Isebia, Jaco Kraan, Ronald de Wit, John W. M. Martens, Leon W. M. M. Terstappen   +8 more
wiley   +1 more source

Generalized Area Spectral Efficiency: An Effective Performance Metric for Green Wireless Communications

, 2014
Area spectral efficiency (ASE) was introduced as a metric to quantify the spectral utilization efficiency of cellular systems. Unlike other performance metrics, ASE takes into account the spatial property of cellular systems. In this paper, we generalize
Hasna, Mazen O., Yang, Hong-Chuan, Zhang, Lei   +2 more
core   +1 more source

Adaptive Subcarrier PSK Intensity Modulation in Free Space Optical Systems [PDF]

, 2010
We propose an adaptive transmission technique for free space optical (FSO) systems, operating in atmospheric turbulence and employing subcarrier phase shift keying (S-PSK) intensity modulation.
Athanasios S. Lioumpas, George K. Karagiannidis, Nestor D. Chatzidiamantis, Senior Member, Senior Member, Shlomi Arnon, Student Member   +6 more
core   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Hybrid M-FSK/DQPSK Modulations for CubeSat Picosatellites [PDF]

, 2013
Conventional CubeSat radio systems typically use one of several basic modulations, such as AFSK, GMSK, BPSK, QPSK and OOK or switch between them on demand if possible.
Mraz, J., Vertat, I.
core   +1 more source

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

SPECTER: efficient evaluation of the spectral EMD

Journal of High Energy Physics
Abstract The Energy Mover’s Distance (EMD) has seen use in collider physics as a metric between events and as a geometric method of defining infrared and collinear safe observables. Recently, the Spectral Energy Mover’s Distance (SEMD) has been proposed as a more analytically tractable alternative to the EMD.
Rikab Gambhir, Andrew J. Larkoski, Jesse Thaler   +2 more
openaire   +4 more sources