Results 61 to 70 of about 193,376 (261)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Laser Phase Noise Tolerant and Power-Fading-Free Hybrid Fiber-Wireless Double-Sideband Transmission With Spectral Efficiency Enhancement

open access: yesIEEE Photonics Journal
The photonics-assisted millimeter-wave (MMW) communication technology is attractive to facilitate the MMW application in the upcoming B5G and 6G networks.
Jiankang Li   +13 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Wireless Energy Harvesting with Cooperative Relaying under the Best Relay Selection Scheme

open access: yesEnergies, 2019
One of the most notable challenges in wireless communications is energy scarcity, which has attracted considerable attention in Fifth Generation (5G) wireless network research.
Admoon Andrawes   +2 more
doaj   +1 more source

Frequency Domain Multi-Carrier Modulation Based on Prolate Spheroidal Wave Functions

open access: yesIEEE Access, 2020
A novel frequency domain multi-carrier modulation (MCM-FD) scheme is proposed based on prolate spheroidal wave functions (PSWFs) for reducing the high complexity in the conventional time domain PSWFs multi-carrier modulation (MCM-PSWFs-TD) schemes.
Hongxing Wang   +4 more
doaj   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

open access: yesFEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Joint Antenna Selection and Adaptive Modulation in MIMO Systems in the Presence of CSI Imperfection

open access: yesInternational Journal of Information and Communication Technology Research, 2011
This paper presents a strategy to combine the antenna selection technique and the adaptive modulation method for multiple input multiple output (MIMO) systems.
Mahshad Hamedanian   +2 more
doaj  

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