Results 31 to 40 of about 17,262 (251)
Spatio–Spectral Limiting on Replacements of Tori by Cubes
Mathematics, 2023 A class of graphs is defined in which each vertex of a discrete torus is replaced by a Boolean hypercube in such a way that vertices in a fixed subset of each replacement cube are adjacent to corresponding vertices of a neighboring replacement cube ...
Jeffrey A. Hogan, Joseph D. Lakey
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Spectral theory of the non-backtracking Laplacian for graphs
Discrete Mathematics, 2023 We introduce a non-backtracking Laplace operator for graphs and we investigate its spectral properties. With the use of both theoretical and computational techniques, we show that the spectrum of this operator captures several structural properties of the graph in a more precise way than the classical operators that have been studied so far in the ...
Jürgen Jost +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A New Family of Graphs and Strong Antireciprocal Eigenvalue Property
Journal of MathematicsSpectral graph theory explores the relationship between the eigenvalues and the structural properties of graphs. This study focuses on the fundamental matrices associated with simple graphs, specifically the adjacency matrix. This work contributes to the
Sadia Akhter +3 more
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Analysis of urban complex networks
Condensed Matter Physics, 2008 We analyze the dual graph representation of urban textures by the methods of complex network theory and spectral graph theory. We present the empirical diagrams of distributions of the nearest and far-away neighbors in the several European compact urban ...
D.Volchenkov
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source