Results 121 to 130 of about 5,431,024 (256)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Bayesian Multi-line Intensity Mapping

The Astrophysical Journal
Line intensity mapping (LIM) has emerged as a promising tool for probing the 3D large-scale structure through the aggregate emission of spectral lines.
Yun-Ting Cheng, Kailai Wang, Benjamin D. Wandelt, Tzu-Ching Chang, Olivier Doré   +4 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Four styles of spectral line shape function and their transformation relation

, 2012
Four styles of spectral line shape function and their transformation relation were investigated theoretically. The photon number and energy distribution as functions of frequency and wavelength resulting from Doppler broadening were investigated, and the
Li, XC, Yin, ZQ, Wu, C, Wang, YJ
core   +1 more source

Observations of Nonthermal Velocities and Comparisons with an Alfvén Wave Turbulence Model in Solar Active Regions

The Astrophysical Journal
We present a study of spectral line width measurements from the Extreme-ultraviolet Imaging Spectrometer on Hinode. We used spectral line profiles of Fe xvi 262.984 Å, Fe xiv 264.787 Å, Fe xiv 270.519 Å, Fe xiv 274.203 Å, and Fe xv 284.160 Å, and studied
M. Asgari-Targhi, D. H. Brooks, M. Hahn, S. Imada, E. Tajfirouze, D. W. Savin   +5 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Method of Digital Processing of Optical Spectra of Magnetron Discharge Plasma

East European Journal of Physics
To solve the actual problems associated with the development of the theory of magnetron discharge and the expansion of its practical application, a digital method of recording and processing the discharge plasma luminescence spectra is proposed in this ...
Inna Afanasieva, Serhii Afanasiev, Valentin Bobkov, Valentina Gritsyna, Anatoliy Skrypnyk   +4 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Speech Spectral Quantizers for Wideband Speech Coding

, 2001
. In this treatise a range of Line Spectrum Frequency (LSF) Vector Quantization (VQ) schemes were studied comparatively, which were designed for wideband speech codecs. Both predictive arrangements and memoryless schemes were investigated.
Guibé, G., How, H T, Hanzo, L
core   +1 more source