Results 101 to 110 of about 1,349,657 (273)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Candidate Spectral Lines at 6 and 15 MeV from GRB 200829A and GRB 160905A

The Astrophysical Journal Letters
The discoveries of the evolving spectral line in gamma-ray burst (GRB) 221009A provide valuable information for understanding its extreme physical environment and emission mechanisms. In this work, we perform a comprehensive search for 3941 GRBs recorded
Tong-Lei Liao, Shuo Xiao, Shao-Lin Xiong, Yan-Qiu Zhang, Wang-Chen Xue, Jiao-Jiao Yang, Zheng-Huo Jiang, Shu-Xu Yi, Zhen Zhang, Shuang-Nan Zhang   +9 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Design of Optical System for Ultra-Large Range Line-Sweep Spectral Confocal Displacement Sensor

Sensors
The spectrum confocal displacement sensor is an innovative type of photoelectric sensor. The non-contact advantages of this method include the capacity to obtain highly accurate measurements without inflicting any harm as well as the ability to determine
Weiguang Yang, Jian Du, Meijie Qi, Jiayue Yan, Mohan Cheng, Zhoufeng Zhang   +5 more
doaj   +1 more source

Spectral shape of one-photon luminescence from single gold nanorods

AIP Advances, 2017
Light emission from gold nanoparticles was investigated with ultra-narrow-band notch filters to obtain the complete spectral shape. The anti-Stokes emission band was observed at all excitation wavelengths.
Te Wen, Yingbo He, Xue-Lu Liu, Miao-Ling Lin, Yuqing Cheng, Jingyi Zhao, Qihuang Gong, Keyu Xia, Ping-Heng Tan, Guowei Lu   +9 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Spectral classification of emission-line galaxies [PDF]

A revised method of classification of narrow line active galaxies and H II region-like galaxies is proposed. It involves the line ratios (O III) lambda 5007/H beta, (N II) lambda 6583/H alpha, (S II) (lambda lambda 6716 = 6731)/H alpha, and (O I) lambda ...
Osterbrock, Donald E., Veilleux, Sylvain
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Near-infrared Spectroscopy of the Sun and Solar Analog Star HD 76151: Compiling an Extensive Line List in the Y, J, H, and K Bands

The Astrophysical Journal
Determining the physical nature of a star requires precise knowledge of its stellar atmospheric parameters, including effective temperature, surface gravity, and metallicity. This study presents a new atomic line list covering a broad spectral range (1–2.
Sena Aleyna Şentürk, Timur Şahin, Ferhat Güney, Selçuk Bilir, Mahmut Marışmak   +4 more
doaj   +1 more source