Results 81 to 90 of about 320,302 (245)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Near-infrared Spectroscopy of the Sun and Solar Analog Star HD 76151: Compiling an Extensive Line List in the Y, J, H, and K Bands

The Astrophysical Journal
Determining the physical nature of a star requires precise knowledge of its stellar atmospheric parameters, including effective temperature, surface gravity, and metallicity. This study presents a new atomic line list covering a broad spectral range (1–2.
Sena Aleyna Şentürk, Timur Şahin, Ferhat Güney, Selçuk Bilir, Mahmut Marışmak   +4 more
doaj   +1 more source

Spectral Correction Impacts of Lightning from Tall Buildings on Channel Temperature Inversion

应用气象学报
During the lightning spectral observation, the spectral intensity is significantly reduced due to instrumental factors and other factors. The spectral intensity attenuation significantly affects the accuracy of temperature calculations. Temperature, as a
Wang Xuejuan, Hua Leyan, Wang Binghao, Xu Weiqun, Lü Weitao, Chen Lüwen, Wu Bin, Qi Qi, Ma Ying, Yang Jing   +9 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

A 1.3cm spectral line study of the W33 region

Astronomy & Astrophysics
At a distance of 2.4 kpc W33 is one of the most prolific sources of molecular line emission, and it is an excellent research target for a centimeter spectral line search. We carried out a 1.3 cm spectral line survey in the frequency range 18–26 GHz.
Tursun Kadirya, Henkel Christian, Esimbek Jarken, Wu Gang, Li Dalei, Tang Xindi, Zhou Jianjun, Wilson Thomas L., Wyrowski Friedrich, Mauersberger Rainer, Immer Katharina, Winkel Benjamin, He Yuxin, Zhou Dongdong, Ma Yingxiu, Sobolev Andrey M., Komesh Toktarkhan, Shen Hailiang   +17 more
doaj   +1 more source

Femtosecond time-evolution of mid-infrared spectral line shapes of Dirac fermions in topological insulators. [PDF]

Sci Rep, 2020
Yeh TT, Tu CM, Lin WH, Cheng CM, Tzeng WY, Chang CY, Shirai H, Fuji T, Sankar R, Chou FC, Gospodinov MM, Kobayashi T, Luo CW.   +12 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Bayesian Multi-line Intensity Mapping

The Astrophysical Journal
Line intensity mapping (LIM) has emerged as a promising tool for probing the 3D large-scale structure through the aggregate emission of spectral lines.
Yun-Ting Cheng, Kailai Wang, Benjamin D. Wandelt, Tzu-Ching Chang, Olivier Doré   +4 more
doaj   +1 more source

Ultrasmall, Ultracompact and Ultrahigh Efficient InGaN Micro Light Emitting Diodes (μLEDs) with Narrow Spectral Line Width. [PDF]

ACS Nano, 2020
Bai J, Cai Y, Feng P, Fletcher P, Zhu C, Tian Y, Wang T.   +6 more
europepmc   +1 more source