Results 81 to 90 of about 1,349,657 (273)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

PyEMILI: A New Generation Computer-aided Spectral Line Identifier

The Astrophysical Journal Supplement Series
Deep high-dispersion spectroscopy of Galactic photoionized gaseous nebulae, mainly planetary nebulae and H ii regions, has revealed numerous emission lines.
Zhijun Tu, Xuan Fang, Robert Williams, Jifeng Liu   +3 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

On broad iron K-alpha lines in Seyfert 1 galaxies

, 1995
The X-ray spectrum obtained by Tanaka et al from a long observation of the active galaxy MCG$-6-30-15$ shows a broad iron K$\alpha$ line skewed to low energies.
Brandt, W. N., Fabian, A. C., Inoue, H., Iwasawa, K., Nandra, K., Otani, C., Reynolds, C. S., Tanaka, Y.   +7 more
core   +1 more source

A new index for detection of submerged aquatic plants under variable quality water: an extension of the soil-line concept

GIScience & Remote Sensing
Submersed aquatic plant (SAP) communities are important determinants of estuarine and lacustrine food web structure, nutrient cycling, and water quality.
Shruti Khanna, Erin L. Hestir, Joaquim Bellvert, Jennifer D. Boyer, Kristen D. Shapiro, Susan L. Ustin   +5 more
doaj   +1 more source

Three-dimensional representation of triple spectral line imaging data as an option for noncontact skin diagnostics. [PDF]

J Biomed Opt, 2022
Ošina I, Spigulis J, Kuzmina I, Dambite L, Berzina A.   +4 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Molecules in Cool Stars: The A2Π − X2Σ+ and the B2Σ+ − X2Σ+ Band Systems of CaCl

The Astrophysical Journal
Cool red giant stars exhibit absorption bands of calcium monochloride (CaCl) in the optical region. In this work, the bands of CaCl corresponding to the A ^2 Π − X ^2 Σ ^+ transition with ${v}^{{\prime} }\leqslant $ 4 and v ″ ≤ 4, and B ^2 Σ ^+ − X ^2 Σ ^
Léo Lavy, Peter F. Bernath
doaj   +1 more source

Skin chromophore mapping by smartphone RGB camera under spectral band and spectral line illumination. [PDF]

J Biomed Opt, 2022
Kuzmina I, Oshina I, Dambite L, Lukinsone V, Maslobojeva A, Berzina A, Spigulis J.   +6 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source