Results 61 to 70 of about 1,349,657 (273)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Obscuring clouds playing hide-and-seek in the Active Nucleus H0557-385

, 2008
This paper reports on two XMM-Newton observations of the Seyfert 1 Galaxy H0557-385 obtained in 2006, which show the source at an historical low flux state, more than a factor of 10 lower than a previous XMM-Newton look in 2002.
A. L. Longinotti, Antonucci, Ashton, Bianchi, Dickey, Fabian, Ghisellini, Guainazzi, Guainazzi, Guainazzi, I. de la Calle, Jansen, L. Ballo, Longinotti, M. Guainazzi, Magdziarz, Matt, Matt, Piconcelli, Pounds, Quadrelli, Reeves, Risaliti, Risaliti, Risaliti, S. Bianchi, Saxton, Turner   +27 more
core   +1 more source

A Graph-Based Method for Molecular Spectral Line Identification

Intelligent Computing
To address the high computational cost associated with molecular identification in spectral lines, we propose a graph-based feature learning framework to determine the molecular composition of spectral lines that incorporates rule-driven and node-level ...
Yijun Pan, Tianwei Zhang, Ruqiao An, Baoquan Gao, Huaxi Chen, Donghui Quan   +5 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A comparison of field-line resonances observed at the Goose Bay and Wick radars [PDF]

Annales Geophysicae, 1997
Previous observations with the Goose Bay HF coherent-scatter radar have revealed structured spectral peaks at ultra-low frequencies. The frequencies of these spectral peaks have been demonstrated to be extremely consistent from day to day.
G. Provan, T. K. Yeoman
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Tomographic RF Spectroscopy of a Trapped Fermi Gas at Unitarity

, 2007
We present spatially resolved radio-frequency spectroscopy of a trapped Fermi gas with resonant interactions and observe a spectral gap at low temperatures.
A. Schirotzek, C. H. Schunck, R. Grimm, R. N. Bracewell, W. Ketterle, Y. Shin   +5 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Determination of Tin by Spectral Lines with Different Sensitivity of Alternating Current Arc Emission Spectroscopy

Yankuang ceshi, 2013
Based on the advantages of simultaneous determination of multiple elements by using different spectral lines of Alternating Current Arc Emission Spectroscopy, samples with a large range of Sn contents were simultaneously determined by the major spectral ...
YU Yu, HE Zhen-yun, MAO Zhen-cai, WEI Yi, YUAN Xiu-ru, LIU Jiang-bin   +5 more
doaj  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1473-1493, June 2026.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source