Results 61 to 70 of about 320,302 (245)

Three-dimensional representation of triple spectral line imaging data as an option for noncontact skin diagnostics. [PDF]

J Biomed Opt, 2022
Ošina I, Spigulis J, Kuzmina I, Dambite L, Berzina A.   +4 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Molecules in Cool Stars: The A2Π − X2Σ+ and the B2Σ+ − X2Σ+ Band Systems of CaCl

The Astrophysical Journal
Cool red giant stars exhibit absorption bands of calcium monochloride (CaCl) in the optical region. In this work, the bands of CaCl corresponding to the A ^2 Π − X ^2 Σ ^+ transition with ${v}^{{\prime} }\leqslant $ 4 and v ″ ≤ 4, and B ^2 Σ ^+ − X ^2 Σ ^
Léo Lavy, Peter F. Bernath
doaj   +1 more source

A new index for detection of submerged aquatic plants under variable quality water: an extension of the soil-line concept

GIScience & Remote Sensing
Submersed aquatic plant (SAP) communities are important determinants of estuarine and lacustrine food web structure, nutrient cycling, and water quality.
Shruti Khanna, Erin L. Hestir, Joaquim Bellvert, Jennifer D. Boyer, Kristen D. Shapiro, Susan L. Ustin   +5 more
doaj   +1 more source

Skin chromophore mapping by smartphone RGB camera under spectral band and spectral line illumination. [PDF]

J Biomed Opt, 2022
Kuzmina I, Oshina I, Dambite L, Lukinsone V, Maslobojeva A, Berzina A, Spigulis J.   +6 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Spectuner: A Framework for Automated Line Identification of Interstellar Molecules

The Astrophysical Journal Supplement Series
Interstellar molecules, which play an important role in astrochemistry, are identified using observed spectral lines. Despite the advent of spectral analysis tools in the past decade, the identification of spectral lines remains a tedious task that ...
Yisheng Qiu, Tianwei Zhang, Thomas Möller, Xue-Jian Jiang, Zihao Song, Huaxi Chen, Donghui Quan   +6 more
doaj   +1 more source

3D NLTE spectral line formation of lithium in late-type stars. [PDF]

Mon Not R Astron Soc, 2021
Wang EX, Nordlander T, Asplund M, Amarsi AM, Lind K, Zhou Y.   +5 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

The A2Π–X2Σ+ Band System of ScO for M-type Star Spectral Analysis

The Astrophysical Journal
M-type stars are the most abundant stars in our Galaxy. Their visible spectra are characterized by strong TiO and VO absorption bands with occasional ScO bands near 6000–6100 Å.
Léo Lavy, Adam Pastorek, Peter F Bernath   +2 more
doaj   +1 more source