Results 61 to 70 of about 1,340,272 (265)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A Graph-Based Method for Molecular Spectral Line Identification

Intelligent Computing
To address the high computational cost associated with molecular identification in spectral lines, we propose a graph-based feature learning framework to determine the molecular composition of spectral lines that incorporates rule-driven and node-level ...
Yijun Pan, Tianwei Zhang, Ruqiao An, Baoquan Gao, Huaxi Chen, Donghui Quan   +5 more
doaj   +1 more source

Vanishing lines in generalized Adams spectral sequences are generic

, 1999
We show that in a generalized Adams spectral sequence, the presence of a vanishing line of fixed slope (at some term of the spectral sequence, with some intercept) is a generic property.Comment: 11 pages.
Hovey, J H Palmieri, J H Smith, M J Hopkins, Palmieri, Ravenel   +5 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Determination of Tin by Spectral Lines with Different Sensitivity of Alternating Current Arc Emission Spectroscopy

Yankuang ceshi, 2013
Based on the advantages of simultaneous determination of multiple elements by using different spectral lines of Alternating Current Arc Emission Spectroscopy, samples with a large range of Sn contents were simultaneously determined by the major spectral ...
YU Yu, HE Zhen-yun, MAO Zhen-cai, WEI Yi, YUAN Xiu-ru, LIU Jiang-bin   +5 more
doaj  

Spectral Analysis of a Self-Similar Sturm-Liouville Operator

, 2004
In this text we describe the spectral nature (pure point or continuous) of a self-similar Sturm-Liouville operator on the line or the half-line. This is motivated by the more general problem of understanding the spectrum of Laplace operators on ...
Sabot, Christophe
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Velocity Modification of Power Spectrum from Absorbing Medium

, 2004
Quantitative description of the statistics of intensity fluctuations within spectral line data cubes introduced in our earlier work is extended to the absorbing media.
A. Lazarian, Cho J., D. Pogosyan, Falgarone E., Goodman J., Green D. A., Kalberla P. M. W., Lazarian A., Lazarian A., Lazarian A., Stenholm L. G., Stutzki J., Velikhov E. P.   +12 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Obscuring clouds playing hide-and-seek in the Active Nucleus H0557-385

, 2008
This paper reports on two XMM-Newton observations of the Seyfert 1 Galaxy H0557-385 obtained in 2006, which show the source at an historical low flux state, more than a factor of 10 lower than a previous XMM-Newton look in 2002.
A. L. Longinotti, Antonucci, Ashton, Bianchi, Dickey, Fabian, Ghisellini, Guainazzi, Guainazzi, Guainazzi, I. de la Calle, Jansen, L. Ballo, Longinotti, M. Guainazzi, Magdziarz, Matt, Matt, Piconcelli, Pounds, Quadrelli, Reeves, Risaliti, Risaliti, Risaliti, S. Bianchi, Saxton, Turner   +27 more
core   +1 more source