Results 71 to 80 of about 1,340,272 (265)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Bayesian Model Reconstruction Based on Spectral Line Observations
The Astrophysical Journal Supplement SeriesSpectral line observations encode a wealth of information. A key challenge, therefore, lies in the interpretation of these observations in terms of models to derive the physical and chemical properties of the astronomical environments from which they ...
Frederik De Ceuster +4 more
doaj +1 more source
Chromospheric polarimetry through multi-line observations of the 850 nm spectral region
, 2016 Future solar missions and ground-based telescopes aim to understand the magnetism of the solar chromosphere. We performed a supporting study in Quintero Noda et al. (2016) focused on the infrared Ca II 8542 A line and we concluded that is one of the best
Anan, T. +8 more
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Doppler Broadening of Spectral Line Shapes in Relativistic Plasmas
Atoms, 2018 In this work, we report some relativistic effects on the spectral line broadening. In particular, we give a new Doppler broadening in extra hot plasmas that takes into account the possible high velocity of the emitters.
Mohammed Tayeb Meftah +4 more
doaj +1 more source
Calibrating and Stabilizing Spectropolarimeters with Charge Shuffling and Daytime Sky Measurements
, 2015 Well-calibrated spectropolarimetry studies at resolutions of $R>$10,000 with signal-to-noise ratios (SNRs) better than 0.01\% across individual line profiles, are becoming common with larger aperture telescopes.
Harrington, David +2 more
core +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
PyEMILI: A New Generation Computer-aided Spectral Line Identifier
The Astrophysical Journal Supplement SeriesDeep high-dispersion spectroscopy of Galactic photoionized gaseous nebulae, mainly planetary nebulae and H ii regions, has revealed numerous emission lines.
Zhijun Tu +3 more
doaj +1 more source
, 2019 Fano resonance exhibiting an asymmetric spectral line shape is a universal phenomenon observed in diverse physical systems. Here we experimentally establish a direct link between the spectral asymmetry parameter and a physically realizable phase factor ...
Ajmal +5 more
core +1 more source