Results 71 to 80 of about 5,257,093 (276)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Line-scan Compressive Raman imaging with spatio-spectral encoding

, 2020
We report a line-scanning imaging modality of Compressive Raman technology with a single-pixel detector. The spatial information along the illumination line is encoded onto one axis of a digital micromirror device, while spectral coding masks are applied
Camille Scotté (12915707), Randy A. Bartels (3952961), Hervé Rigneault (2482108), Siddharth Sivankutty (3959567)   +3 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Spectrally resolved observations of atmospheric emitted radiance in the H2O rotation band [PDF]

, 2008
This paper presents the project Earth Cooling by Water Vapor Radiation, an observational programme, which aims at developing a database of spectrally resolved far infrared observations, in atmospheric dry conditions, in order to validate radiative ...
T. Di Iorio, PAPANDREA, ENZO, TODINI, GIULIO, Rizzi, R., BOZZO A, Bianchini, G., CACCIANI, Marco, Di Iorio, T., L. PALCHETTI, PALCHETTI L, Esposito, F., Di Sarra, A., DI IORIO, Tatiana, A. BOZZO, Calvello, M. R., Maestri, T., G. MUSCARI, G. BIANCHINI, Fua, D., Masiello, G., R. RESTIERI, Carlotti, M., FIOCCO G, P. DI GIROLAMO, DI LIBERTO L, E. TOSI, E. PAPANDREA, SERIO, Carmine, D. SUMMA, RIZZI R, CARLOTTI, MASSIMO, M. R. CALVELLO, CALVELLO M. R, G. PAVESE, BIANCHINI G, Papandrea, E., Tosi, E., R. Bhawar, FUA', DANIELE, G. GRIECO, MUSCARI G, Todini, G., DI IORIO T, Pavese, G., TODINI G. , TOSI E., MAESTRI, TIZIANO, SUMMA D, RIZZI, ROLANDO, CARLOTTI M, Romano, F., Bozzo, A., Di Girolamo, P., G. TODINI, V. CUOMO, CUOMO, Vincenzo, BOZZO, ALESSIO, Cacciani, M., RESTIERI R, DI GIROLAMO, Paolo, Bhawar, R., G. MASIELLO, Fiocco, G., R. RIZZI, Palchetti, L., Muscari, G., M. Cacciani, Di Liberto, L., PAPANDREA E, G. Fiocco, BHAWAR R, TOSI, ENNIO, FIOCCO, Giorgio, ESPOSITO, Francesco, MAESTRI T, C. SERIO, Serio, C., D. Fua`, Summa, D., F. ROMANO, F. ESPOSITO, A. DI SARRA, Cuomo, V., DI SARRA A, DI LIBERTO, Luca, M. CARLOTTI, PAVESE G, Restieri, R., MASIELLO, Guido, Castagnoli, F., Grieco, G., F. CASTAGNOLI, GRIECO G, T. MAESTRI, L. Di Liberto, CACCIANI M, ROMANO F, FUA D, CASTAGNOLI F   +97 more
core   +1 more source