Results 71 to 80 of about 1,349,657 (273)

Bayesian Model Reconstruction Based on Spectral Line Observations

The Astrophysical Journal Supplement Series
Spectral line observations encode a wealth of information. A key challenge, therefore, lies in the interpretation of these observations in terms of models to derive the physical and chemical properties of the astronomical environments from which they ...
Frederik De Ceuster, Thomas Ceulemans, Leen Decin, Taïssa Danilovich, Jeremy Yates   +4 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Spectral Analysis of a Self-Similar Sturm-Liouville Operator

, 2004
In this text we describe the spectral nature (pure point or continuous) of a self-similar Sturm-Liouville operator on the line or the half-line. This is motivated by the more general problem of understanding the spectrum of Laplace operators on ...
Sabot, Christophe
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Chromospheric polarimetry through multi-line observations of the 850 nm spectral region

, 2016
Future solar missions and ground-based telescopes aim to understand the magnetism of the solar chromosphere. We performed a supporting study in Quintero Noda et al. (2016) focused on the infrared Ca II 8542 A line and we concluded that is one of the best
Anan, T., Carlsson, M., Ichimoto, K., Katsukawa, Y., Noda, C. Quintero, Oba, T., Rodriguez, J. de la Cruz, Shimizu, T., Suematsu, Y.   +8 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Spectral monitoring of AGNs: Preliminary results for Ark 564 and Arp 102B

, 2011
We present preliminary results of the long term spectral monitoring of two active galactic nuclei with different broad line shapes: Ark 564 and Arp 102B.
Burenkov, A. N., Chavushyan, V. H., Ilic, D., Kovacevic, A., Kovacevic, J., Popovic, L. C., Shapovalova, A. I.   +6 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Velocity Modification of Power Spectrum from Absorbing Medium

, 2004
Quantitative description of the statistics of intensity fluctuations within spectral line data cubes introduced in our earlier work is extended to the absorbing media.
A. Lazarian, Cho J., D. Pogosyan, Falgarone E., Goodman J., Green D. A., Kalberla P. M. W., Lazarian A., Lazarian A., Lazarian A., Stenholm L. G., Stutzki J., Velikhov E. P.   +12 more
core   +1 more source

Doppler Broadening of Spectral Line Shapes in Relativistic Plasmas

Atoms, 2018
In this work, we report some relativistic effects on the spectral line broadening. In particular, we give a new Doppler broadening in extra hot plasmas that takes into account the possible high velocity of the emitters.
Mohammed Tayeb Meftah, Hadda Gossa, Kamel Ahmed Touati, Keltoum Chenini, Amel Naam   +4 more
doaj   +1 more source