Results 121 to 130 of about 791,277 (228)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Sensitivity of Spectral Lines to Granulation: The Sun

The Astrophysical Journal
The intrinsic variability of stars, due to acoustic oscillations, surface granulation, and magnetic activity, introduces radial velocity (RV) jitter in spectral lines, obscuring true planetary signals and hindering the detection of Earth-like planets ...
K. Sowmya, A. I. Shapiro, V. Vasilyev, V. Witzke, A. Collier Cameron, S. K. Solanki   +5 more
doaj   +1 more source

Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Planetary and cometary atmospheres [version 1; peer review: 2 approved]

Open Research Europe
The study of planets and small bodies within our Solar System is fundamental for understanding the formation and evolution of the Earth and other planets.
Conor Nixon, Arielle Moullet, Nicholas Teanby, Imke de Pater, Steven Charnley, Bryan Butler, Pamela Klaassen, Raphael Moreno, Stefanie Milam, Mark Booth, Amelie Saintonge, Claudia Cicone, Martin Cordiner, Tony Mroczkowski, Doug Johnstone, Luca Di Mascolo, Minju Lee, Eelco van Kampen, Thomas Maccarone, Daizhong Liu, Matthew Smith, Sven Wedemeyer, Alexander Thelen, Thibault Cavalie, Leigh N. Fletcher, Richard Cosentino, Katherine de Kleer, Mark Gurwell, Emmanuel Lellouch, Yi-Jehng Kuan   +29 more
doaj   +1 more source

Submillimeter, millimeter, and microwave spectral line catalogue [PDF]

A computer accessible catalogue of submillimeter, millimeter and microwave spectral lines in the frequency range between 0 and 3000 GHZ (i.e., wavelengths longer than 100 mu m) is presented which can be used a planning guide or as an aid in the ...
Pickett, H. M., Poynter, R. L.
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Effect of genetic distances of different genotypes of maize on the authenticity of single seeds detected by NIR spectroscopy

Frontiers in Plant Science
IntroductionNIR spectroscopy combined with chemometric algorithms has been widely used for seed authenticity detection. However, the study of seed genetic distance, an internal feature that affects the discriminative performance of classification models,
Yongqin Yang, Rashaun Candace Harrison, Dun Zhang, Binghui Shen, Yanlu Yan, Dingming Kang   +5 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

STUDY OF THE NATURAL WATER TOTAL GROSS COMPOSITION INFLUENCE TO THE ANALYTICAL SIGNAL MAGNITUDE ON TWO JETS PLAZMATRON

Вестник. Серия физическая, 2008
It was study the influence of the natural water gross composition to spectral lines intensity on length of plasma. It installed that the gross composition total content didn’t influence to spectral lines intensity distribution of microelement’s atoms and
G.Zh. Dorzhueva, К. Urmanbetov, R.А. Tashtanov   +2 more
doaj