Results 121 to 130 of about 251,815 (286)

High-Throughput Cell Imaging and Classification by Narrowband and Low-Spectral-Resolution Raman Microscopy

open access: yes, 2019
We investigated the use of narrowband Raman spectra for rapid label-free molecular imaging aimed at cell classification using principal component regression and linear discriminant analysis.
Yasuaki Kumamoto (1778221)   +11 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Sensitivity of Spectral Lines to Granulation: The Sun

open access: yesThe Astrophysical Journal
The intrinsic variability of stars, due to acoustic oscillations, surface granulation, and magnetic activity, introduces radial velocity (RV) jitter in spectral lines, obscuring true planetary signals and hindering the detection of Earth-like planets ...
K. Sowmya   +5 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

The relativistic computations of spectral lines of 129Xe I

open access: yes, 2019
In this paper, we present our achievement on the relativistic computations of the spectral lines for the levels belonging to the 6s[k]J, 4f[k]J, 5d[k]J, 6p[k]J, 7s[k]J, 5f[k]J, 6d[k]J, 7p[k]J and 8s[k]J intermediate Rydberg series in the heavy xenon-129 ...
Wa'el Salah, Ola Hassouneh
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Effect of genetic distances of different genotypes of maize on the authenticity of single seeds detected by NIR spectroscopy

open access: yesFrontiers in Plant Science
IntroductionNIR spectroscopy combined with chemometric algorithms has been widely used for seed authenticity detection. However, the study of seed genetic distance, an internal feature that affects the discriminative performance of classification models,
Yongqin Yang   +5 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

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