Results 111 to 120 of about 2,504,636 (253)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Spectuner: A Framework for Automated Line Identification of Interstellar Molecules

The Astrophysical Journal Supplement Series
Interstellar molecules, which play an important role in astrochemistry, are identified using observed spectral lines. Despite the advent of spectral analysis tools in the past decade, the identification of spectral lines remains a tedious task that ...
Yisheng Qiu, Tianwei Zhang, Thomas Möller, Xue-Jian Jiang, Zihao Song, Huaxi Chen, Donghui Quan   +6 more
doaj   +1 more source

Atacama Large Aperture Submillimeter Telescope (AtLAST) Science: Planetary and Cometary Atmospheres [version 2; peer review: 3 approved]

Open Research Europe
The study of planets and small bodies within our Solar System is fundamental for understanding the formation and evolution of the Earth and other planets.
Conor Nixon, Arielle Moullet, Nicholas Teanby, Imke de Pater, Steven Charnley, Bryan Butler, Pamela Klaassen, Raphael Moreno, Stefanie Milam, Mark Booth, Amelie Saintonge, Claudia Cicone, Martin Cordiner, Tony Mroczkowski, Doug Johnstone, Luca Di Mascolo, Minju Lee, Eelco van Kampen, Thomas Maccarone, Daizhong Liu, Matthew Smith, Sven Wedemeyer, Alexander Thelen, Thibault Cavalie, Leigh N. Fletcher, Richard Cosentino, Katherine de Kleer, Mark Gurwell, Emmanuel Lellouch, Yi-Jehng Kuan   +29 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

The Ocean Swim: Rethinking Community in an Early Childhood Education Performing Arts Research Initiative

, 2016
This chapter describes a community research project called MAPS Move, Act, Play, Sing), which involved community artists in music, dance and drama working with three early childhood education centres in Auckland, New Zealand. The MAPS project developed a
David Lines, Lines, David
core   +1 more source

Vinyl cyanide (CH₂CHCN) in interstellar space: potential spectral lines for its detection. [PDF]

Heliyon, 2019
Sharma MK.
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Importance evaluation of spectral lines in Laser-induced breakdown spectroscopy for classification of pathogenic bacteria. [PDF]

Biomed Opt Express, 2018
Wang Q, Teng G, Qiao X, Zhao Y, Kong J, Dong L, Cui X.   +6 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Planetary and cometary atmospheres [version 1; peer review: 2 approved]

Open Research Europe
The study of planets and small bodies within our Solar System is fundamental for understanding the formation and evolution of the Earth and other planets.
Conor Nixon, Arielle Moullet, Nicholas Teanby, Imke de Pater, Steven Charnley, Bryan Butler, Pamela Klaassen, Raphael Moreno, Stefanie Milam, Mark Booth, Amelie Saintonge, Claudia Cicone, Martin Cordiner, Tony Mroczkowski, Doug Johnstone, Luca Di Mascolo, Minju Lee, Eelco van Kampen, Thomas Maccarone, Daizhong Liu, Matthew Smith, Sven Wedemeyer, Alexander Thelen, Thibault Cavalie, Leigh N. Fletcher, Richard Cosentino, Katherine de Kleer, Mark Gurwell, Emmanuel Lellouch, Yi-Jehng Kuan   +29 more
doaj   +1 more source