Results 91 to 100 of about 791,277 (228)

Bayesian Multi-line Intensity Mapping

The Astrophysical Journal
Line intensity mapping (LIM) has emerged as a promising tool for probing the 3D large-scale structure through the aggregate emission of spectral lines.
Yun-Ting Cheng, Kailai Wang, Benjamin D. Wandelt, Tzu-Ching Chang, Olivier Doré   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Temperature distribution in a stellar atmosphere diagnostic basis [PDF]

A stellar chromosphere is considered a region where the temperature increases outward and where the temperature structure of the gas controls the shape of the spectral lines.
Jefferies, J. T., Morrison, N. D.
core   +1 more source

Spectral Optical Monitoring of the Narrow Line Seyfert 1 galaxy Ark 564

, 2010
We present the results of a long-term (1999--2010) spectral optical monitoring campaign of the active galactic nucleus (AGN) Ark 564, which shows a strong Fe II line emission in the optical. This AGN is a narrow line Seyfert 1 (NLS1) galaxies, a group of
A. I. Shapovalova, A. Kovačević, A. Mercado, A. N. Burenkov, Alexander, Bischoff, Boller, Collier, Crenshaw, Crenshaw, Cruise, D. Dultzin, D. Ilić, de Vaucouleurs, E. Benítez, E. de la Fuente, Giannuzzo, J. Kovačević, J. León-Tavares, J. R. Valdes, J. Torrealba, Kollatschny, Kollatschny, Kollatschny, Kovačević, Kuehn, Kuraszkiewicz, L. Carrasco, L. Č. Popović, Leighly, Leighly, Marziani, Matsumoto, N. G. Bochkarev, O'Brien, Peterson, Peterson, Popović, Popović, Pounds, Rodríguez-Ardila, Shemmer, Sulentic, Sulentic, Turner, V. H. Chavushyan, W. Kollatschny, Zhang   +47 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Random sampling technique for ultra-fast computations of molecular opacities for exoplanet atmospheres

, 2017
Opacities of molecules in exoplanet atmospheres rely on increasingly detailed line-lists for these molecules. The line lists available today contain for many species up to several billions of lines.
Min, Michiel
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Optical spectrum of proflavine and its ions

, 2010
Motivated by possible astrophysical and biological applications we calculate visible and near UV spectral lines of proflavine (C13H11N3, 3,6-diaminoacridine) in vacuum, as well as its anion, cation, and dication.
A. Bonaca, Bauschlicher, Becke, Castro, Castro, Clemett, De Silvestri, Destree, Ehrenfreund, G. Bilalbegović, Giannozzi, Godby, Herbig, Hirata, Hobbs, Hudgins, Jain, Jenniskens, Jones, Koch, Kokalj, Le Page, Lee, Lepp, Lerman, Malloci, Malloci, Marques, Martin, Mataga, Neumann, Perdew, Pileni, Rappe, Rocca, Runge, Sarre, Sarre, Sarre, Schulman, Snow, Thaddeus, Tielens, Tozzini, Troullier, Tuairisg, Varsano, Walker, Weisman, Yabana   +49 more
core   +1 more source