Results 81 to 90 of about 223,996 (243)

Atacama Large Aperture Submillimeter Telescope (AtLAST) Science: Planetary and Cometary Atmospheres [version 2; peer review: 3 approved]

Open Research Europe
The study of planets and small bodies within our Solar System is fundamental for understanding the formation and evolution of the Earth and other planets.
Conor Nixon, Arielle Moullet, Nicholas Teanby, Imke de Pater, Steven Charnley, Bryan Butler, Pamela Klaassen, Raphael Moreno, Stefanie Milam, Mark Booth, Amelie Saintonge, Claudia Cicone, Martin Cordiner, Tony Mroczkowski, Doug Johnstone, Luca Di Mascolo, Minju Lee, Eelco van Kampen, Thomas Maccarone, Daizhong Liu, Matthew Smith, Sven Wedemeyer, Alexander Thelen, Thibault Cavalie, Leigh N. Fletcher, Richard Cosentino, Katherine de Kleer, Mark Gurwell, Emmanuel Lellouch, Yi-Jehng Kuan   +29 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Spectuner: A Framework for Automated Line Identification of Interstellar Molecules

The Astrophysical Journal Supplement Series
Interstellar molecules, which play an important role in astrochemistry, are identified using observed spectral lines. Despite the advent of spectral analysis tools in the past decade, the identification of spectral lines remains a tedious task that ...
Yisheng Qiu, Tianwei Zhang, Thomas Möller, Xue-Jian Jiang, Zihao Song, Huaxi Chen, Donghui Quan   +6 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Planetary and cometary atmospheres [version 1; peer review: 2 approved]

Open Research Europe
The study of planets and small bodies within our Solar System is fundamental for understanding the formation and evolution of the Earth and other planets.
Conor Nixon, Arielle Moullet, Nicholas Teanby, Imke de Pater, Steven Charnley, Bryan Butler, Pamela Klaassen, Raphael Moreno, Stefanie Milam, Mark Booth, Amelie Saintonge, Claudia Cicone, Martin Cordiner, Tony Mroczkowski, Doug Johnstone, Luca Di Mascolo, Minju Lee, Eelco van Kampen, Thomas Maccarone, Daizhong Liu, Matthew Smith, Sven Wedemeyer, Alexander Thelen, Thibault Cavalie, Leigh N. Fletcher, Richard Cosentino, Katherine de Kleer, Mark Gurwell, Emmanuel Lellouch, Yi-Jehng Kuan   +29 more
doaj   +1 more source

Vinyl cyanide (CH₂CHCN) in interstellar space: potential spectral lines for its detection. [PDF]

Heliyon, 2019
Sharma MK.
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Importance evaluation of spectral lines in Laser-induced breakdown spectroscopy for classification of pathogenic bacteria. [PDF]

Biomed Opt Express, 2018
Wang Q, Teng G, Qiao X, Zhao Y, Kong J, Dong L, Cui X.   +6 more
europepmc   +1 more source