Results 161 to 170 of about 47,396,763 (332)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Pseudo-spectral method for controlling the drug dosage in cancer. [PDF]
IET Syst Biol, 2020 Nazari M, Nazari M, Noori Skandari MH.
europepmc +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
A New Pseudo-Spectral Method Using the Discrete Cosine Transform. [PDF]
J Imaging, 2020 Ito I.
europepmc +1 more source
Estimating the irradiance spectrum from measurements in a limited number of spectral bands
, 2006 Accurate measurement and characterisation of fluctuations in the irradiance environment is important for many areas of optical remote sensing. This paper describes a method of estimating spectral irradiance over the region 400 – 1000 nm from the radiance
Milton, E.J., Rollin, E.M.
core +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
, 1996 A new compact finite difference-Fourier spectral hybrid method for solving the three dimensional incompressible Navier-Stokes equations is developed in the present paper.
凌国灿 +2 more
core +1 more source
Influence of the Elastoplastic Strain on Fatigue Durability Determined with the Use of the Spectral Method. [PDF]
Materials (Basel), 2020 Böhm M, Kowalski M, Niesłony A.
europepmc +1 more source