Results 61 to 70 of about 479,061 (253)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Explicit collocation algorithm for the nonlinear fractional Duffing equation via third-kind Chebyshev polynomials [PDF]
Iranian Journal of Numerical Analysis and OptimizationHerein, we propose an accurate algorithm to approximate the solution of the nonlinear fractional-order Duffing equation (NFDE). The algorithm is based on using shifted Chebyshev polynomials of the third-kind as basis functions and the spectral ...
Y.H. Youssri +3 more
doaj +1 more source
Computation of Density Perturbation and Energy Flux of Internal Waves from Experimental Data
Fluids, 2020 We hereby present two different spectral methods for calculating the density anomaly and the vertical energy flux from synthetic Schlieren data, for a periodic field of linear internal waves (IW) in a density-stratified fluid with a uniform buoyancy ...
Lucie Bordois +2 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
FEBS Letters, EarlyView.Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Machine-learning-based spectral methods for partial differential equations. [PDF]
Sci Rep, 2023 Meuris B, Qadeer S, Stinis P.
europepmc +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Two Chebyshev Spectral Methods for Solving Normal Modes in Atmospheric Acoustics. [PDF]
Entropy (Basel), 2021 Wang Y, Tu H, Liu W, Xiao W, Lan Q.
europepmc +1 more source