Results 71 to 80 of about 479,061 (253)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Accurate Chebyshev collocation solutions for the biharmonic eigenproblem on a rectangle

open access: yesJournal of Numerical Analysis and Approximation Theory, 2017
We are concerned with accurate Chebyshev collocation (ChC) solutions to fourth order eigenvalue problems. We consider the 1D case as well as the 2D case.
Imre Boros
doaj   +2 more sources

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Thermal analysis of extended surfaces using deep neural networks

open access: yesOpen Physics
The complexity of thermal analysis in practical systems has emerged as a subject of interest in various fields of science and engineering. Extended surfaces, commonly called fins, are crucial cooling and heating mechanisms in many applications, such as ...
Oloniiju Shina Daniel   +2 more
doaj   +1 more source

Novel derivative operational matrix in Caputo sense with applications

open access: yesJournal of Taibah University for Science
The main objective of this study is to present a computationally efficient numerical method for solving fractional-order differential equations with initial conditions.
Danish Zaidi   +3 more
doaj   +1 more source

The Synthesis and the Biological Evaluation of New Thiazolidin-4-one Derivatives Containing a Xanthine Moiety

open access: yesMolecules, 2013
Starting from theophylline (1,3-dimethylxanthine) new thiazolidin-4-one derivatives 7a1–7, 7b1–7 have been synthesized as potential antidiabetic drugs.
Lenuta Profire   +4 more
doaj   +1 more source

Compressive Spectral Renormalization Method

open access: yes, 2016
In this paper a novel numerical scheme for finding the sparse self-localized states of a nonlinear system of equations with missing spectral data is introduced. As in the Petviashivili's and the spectral renormalization method, the governing equation is transformed into Fourier domain, but the iterations are performed for far fewer number of spectral ...
openaire   +4 more sources

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

open access: yesFEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy