Results 71 to 80 of about 1,565,423 (283)

Spectral methods for discontinuous problems [PDF]

open access: yes
Spectral methods yield high-order accuracy even when applied to problems with discontinuities, though not in the sense of pointwise accuracy. Two different procedures are presented which recover pointwise accurate approximations from the spectral ...
Abarbanel, S., Gottlieb, D., Tadmor, E.
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

A review of spectral methods [PDF]

open access: yes
An outline for spectral methods for partial differential equations is presented. The basic spectral algorithm is defined, collocation are emphasized and the main advantage of the method, the infinite order of accuracy in problems with smooth solutions ...
Lustman, L.
core   +1 more source

Unbiased flux calibration methods for spectral-line radio observations

open access: yes, 2012
Position and frequency switching techniques used for the removal of the bandpass dependence of radio astronomical spectra are presented and discussed in detail. Both methods are widely used, although the frequency dependence of the system temperature and/
A. Kraus   +8 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Multilayer Structured NMF for Spectral Unmixing of Hyperspectral Images

open access: yes, 2015
One of the challenges in hyperspectral data analysis is the presence of mixed pixels. Mixed pixels are the result of low spatial resolution of hyperspectral sensors. Spectral unmixing methods decompose a mixed pixel into a set of endmembers and abundance
Ghassemian, Hassan, Rajabi, Roozbeh
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Spectral methods in fluid dynamics [PDF]

open access: yes
Fundamental aspects of spectral methods are introduced. Recent developments in spectral methods are reviewed with an emphasis on collocation techniques.
Hussaini, M. Y., Zang, T. A.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

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