Results 71 to 80 of about 13,124,790 (289)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Stochastic Spectral and Conjugate Descent Methods
, 2018 The state-of-the-art methods for solving optimization problems in big dimensions are variants of randomized coordinate descent (RCD). In this paper we introduce a fundamentally new type of acceleration strategy for RCD based on the augmentation of the ...
Kovalev, Dmitry +3 more
core
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
On Fourier Series in the Context of Jacobi Matrices
AxiomsWe investigate the properties of matrices that emerge from the application of Fourier series to Jacobi matrices. Specifically, we focus on functions defined by the coefficients of a Fourier series expressed in orthogonal polynomials.
José M. A. Matos +2 more
doaj +1 more source
awesome-spectral-indices/spectral: 0.2.0
, 2022 Spectral v0.2.0 :artificial_satellite: :seedling: Improvements The Awesome Spectral Indices list was upgraded to v0.2 ...
David Montero Loaiza, actions-user
core +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Spectral Matching through Data Compression [PDF]
, 2011 This paper proposes to use compression-based similarity measures to cluster spectral signatures on the basis of their similarities. Such universal distances estimate the shared information between two objects by comparing their compression factors ...
Avbelj, Janja +4 more
core
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The Spectral-Element and Pseudo-Spectral Methods: A Comparative Study
, 2010 Turbulent and transitional channel flow simulations have been performed in order to assess the differences concerning speed and accuracy in the pseudo-spectral code simson and the spectral-element code nek5000.
Henningson, Dan S., +7 more
core +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source