Results 91 to 100 of about 13,856,756 (258)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Thermal analysis of extended surfaces using deep neural networks

Open Physics
The complexity of thermal analysis in practical systems has emerged as a subject of interest in various fields of science and engineering. Extended surfaces, commonly called fins, are crucial cooling and heating mechanisms in many applications, such as ...
Oloniiju Shina Daniel, Tijani Yusuf Olatunji, Otegbeye Olumuyiwa   +2 more
doaj   +1 more source

Novel derivative operational matrix in Caputo sense with applications

Journal of Taibah University for Science
The main objective of this study is to present a computationally efficient numerical method for solving fractional-order differential equations with initial conditions.
Danish Zaidi, Imran Talib, Muhammad Bilal Riaz, Parveen Agarwal   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Efficient Spectral Galerkin and Collocation Approaches Using Telephone Polynomials for Solving Some Models of Differential Equations with Convergence Analysis

Mathematics
This study presents Galerkin and collocation algorithms based on Telephone polynomials (TelPs) for effectively solving high-order linear and non-linear ordinary differential equations (ODEs) and ODE systems, including those with homogeneous and ...
Ramy Mahmoud Hafez, Hany Mostafa Ahmed, Omar Mazen Alqubori, Amr Kamel Amin, Waleed Mohamed Abd-Elhameed   +4 more
doaj   +1 more source

The Synthesis and the Biological Evaluation of New Thiazolidin-4-one Derivatives Containing a Xanthine Moiety

Molecules, 2013
Starting from theophylline (1,3-dimethylxanthine) new thiazolidin-4-one derivatives 7a1–7, 7b1–7 have been synthesized as potential antidiabetic drugs.
Lenuta Profire, Dan Lupascu, Liliana Foia, Florentina Geanina Lupascu, Oana Maria Dragostin   +4 more
doaj   +1 more source

Impact of Visual Design Elements and Principles in Human Electroencephalogram Brain Activity Assessed with Spectral Methods and Convolutional Neural Networks. [PDF]

Sensors (Basel), 2021
Cabrera FE, Sánchez-Núñez P, Vaccaro G, Peláez JI, Escudero J.   +4 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

High-Order Spectral Scheme with Structure Maintenance and Fast Memory Algorithm for Nonlocal Nonlinear Diffusion Equations

AppliedMath
We develop a fast numerical method for solving nonlinear diffusion equations with memory phenomena, a class of problems arising within viscoelastic materials, anomalous transport, and hereditary systems.
Kadrzhan Shiyapov, Zhanars Abdiramanov, Zhuldyz Issa, Aruzhan Zhumaseyitova   +3 more
doaj   +1 more source