Results 101 to 110 of about 13,856,756 (258)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Seismic Response Analysis of a Six-Story Building in Sofia Using Accelerograms from the 2012 Mw5.6 Pernik Earthquake

Applied Sciences
On 22 May 2012, a magnitude Mw 5.6 earthquake struck the Pernik region of western Bulgaria, causing structural damage in nearby cities, including Sofia. This study assesses the seismic response of a six-story reinforced concrete building in central Sofia,
Lyubka Pashova, Emil Oynakov, Ivanka Paskaleva, Radan Ivanov   +3 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Mineralogy and Spectra Study on Dougeng Stone from Shoushan, Fujian Province

, 2020
This paper studied main characteristics of Dougeng stone, by means of several Spectra methods like X-ray powder diffraction (XRD) , Fourier transform infrared spectroscopy (FTIR) and Raman spectra, as well as mineralogical methods like hydrostatic ...
Xi Jia-xin, Chen Tao
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

On-Line Component Analysis of Cement Powder Using LIBS Technology

, 2019
In the process of cement production in the industrial field, the content of each component in the cement directly affects the quality of the cement. Therefore, it is of great significance to quickly and accurately monitor the content of each component in
Sun Lan-xiang, Qi Li-feng, Zeng Peng, Shi You-zhen, Zhou Zhong-han, Zhang Peng, Guo Zhi-wei, Wang Wei, Yu Hai-bin   +8 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Non-Polynomial Collocation Spectral Scheme for Systems of Nonlinear Caputo–Hadamard Differential Equations

Fractal and Fractional
In this paper, we provide a collocation spectral scheme for systems of nonlinear Caputo–Hadamard differential equations. Since the Caputo–Hadamard operators contain logarithmic kernels, their solutions can not be well approximated using the usual ...
Mahmoud A. Zaky, Ibrahem G. Ameen, Mohammed Babatin, Ali Akgül, Magda Hammad, António M. Lopes   +5 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spectral methods for limited area models [PDF]

, 1984
1984 Fall.Includes bibliographical references (pages143-150).This study investigates the usefulness of Chebyshev spectral methods in limited area atmospheric modeling.
Schubert, Wayne H., advisor, Stevens, Duane E., committee member, Fulton, Scott R., author, Taylor, Gerald D., committee member, Krueger, David A., committee member, Johnson, Richard H. (Richard Harlan), committee member   +5 more
core