Results 111 to 120 of about 13,124,790 (289)

Seismic Response Analysis of a Six-Story Building in Sofia Using Accelerograms from the 2012 Mw5.6 Pernik Earthquake

Applied Sciences
On 22 May 2012, a magnitude Mw 5.6 earthquake struck the Pernik region of western Bulgaria, causing structural damage in nearby cities, including Sofia. This study assesses the seismic response of a six-story reinforced concrete building in central Sofia,
Lyubka Pashova, Emil Oynakov, Ivanka Paskaleva, Radan Ivanov   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Non-Polynomial Collocation Spectral Scheme for Systems of Nonlinear Caputo–Hadamard Differential Equations

Fractal and Fractional
In this paper, we provide a collocation spectral scheme for systems of nonlinear Caputo–Hadamard differential equations. Since the Caputo–Hadamard operators contain logarithmic kernels, their solutions can not be well approximated using the usual ...
Mahmoud A. Zaky, Ibrahem G. Ameen, Mohammed Babatin, Ali Akgül, Magda Hammad, António M. Lopes   +5 more
doaj   +1 more source

The Study of Oil Film Thickness Measurement on Water Surface Based on Laser Raman Spectroscopy

, 2018
In order to realize the fast and non-contact detection of oil film thickness on water surface, a system based on laser Raman spectroscopy technologywas introduced in this paper. The 532 nm laser was used as the exciting source, and the result shows there
Feng Wei-wei, Cai Zong-qi, Wang Chuan-yuan   +2 more
core   +1 more source

Spectroscopic Imaging of Cutaneous Squamous Cell Carcinoma Based on Acousto-Optic Filtering

, 2020
Noncollinear acousto-optic tunable filter (AOTF) based on TeO2 is a type of good light splitting device with the electric tuning. Because of its advantages of compact size, high stability, fast tuning, and being easy to carry out, it has high practical ...
Huang Zu-fang, Qiu Ze-long, Zhang Chun-guang, Wang Hao, Xing Yu-wei, Sheng Zhen-fei, Qiu Wei-jie, Zhang Xiao-fa, Lin Bin-bin, Liu Yi-ping, Duan Mao-qiang, Huang Xiao-li, Huang Xi, Tan Zhi-wei, Wang Peng-chong, Liu Wen-yao   +15 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source