Results 131 to 140 of about 24,560 (299)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Efficient computation of spectral moments for determination of random response statistics

, 2004
This paper will first review the use of temporal spectral moments, and then propose an efficient running sum technique to determine the spectral moments frequency by frequency.
Sweitzer, Karl A., Genberg, Victor L., Bishop, Neil W.M.   +2 more
core  

QUIJOTE scientific results

Astronomy & Astrophysics
We introduce a novel approach to estimate the spectral index, βs, of polarised synchrotron emission, combining the moment expansion of Cosmic Microwave Background foregrounds and the constrained Internal Linear Combination method.
Adak D., Rubiño-Martín J. A., Génova-Santos R. T., Remazeilles M., Almeida A., Aryan K., Ashdown M., Barreiro R. B., Bose U., Cepeda-Arroita R., Casas J. M., Fernández-Torreiro M., Martínez-Gonzalez E., Poidevin F., Rebolo R., Vielva P.   +15 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Determination of molecular light scattering spectral lines parameters with help of regularized frequency moments

, 1997
A new direct method of determination of spectral line parameters is expounded by means of regularized frequency moments, complete set of which is well defined even for slowly declined spectral functions of Lorentz type.
Osmanov, S. A., Malomuzh, N. P., Faizullaev, Sh. F., Lishchuk, S. V.   +3 more
core  

A commutative noncommutative fractal geometry

, 2011
In this thesis examples of spectral triples, which represent fractal sets, are examined and new insights into their noncommutative geometries are obtained.
Samuel, Tony; id_orcid, Samuel, Anthony
core   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Determination of Derivative Moments using Two Slanted Hot-Wires and a Spectral method

, 1993
A method to determine derivative moments using slanted hot-wires and a spectral method has been developed. The general idea is to minimize measuring volume by using only two hot-wires, and a post-processing of the measurement data.
Löfdahl, Lennart,, Lerner, Mikael S.,, Johansson, Bert,, Bergh, Jöran,   +3 more
core   +2 more sources