Results 91 to 100 of about 927,050 (285)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Principal Functions of Non-Selfadjoint Difference Operator with Spectral Parameter in Boundary Conditions

open access: yesAbstract and Applied Analysis, 2011
We investigate the principal functions corresponding to the eigenvalues and the spectral singularities of the boundary value problem (BVP) 𝑎𝑛−1𝑦𝑛−1+𝑏𝑛𝑦𝑛+𝑎𝑛𝑦𝑛+1=𝜆𝑦𝑛, 𝑛∈ℕ and (𝛾0+𝛾1𝜆)𝑦1+(𝛽0+𝛽1𝜆)𝑦0=0, where (𝑎𝑛) and (𝑏𝑛) are complex ...
Murat Olgun   +2 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Phase singularities in isotropic random waves [PDF]

open access: yes, 2000
The singularities of complex scalar waves are their zeros; these are dislocation lines in space, or points in the plane. For waves in space, and waves in the plane (propagating in two dimensions, or sections of waves propagating in three), we calculate ...
Dennis, MR   +5 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Study on Spectral Interference in the Determination of Vanadium by ICP-OES

open access: yes, 2020
Vanadium is an important scarce resource and strategic metal, and often coexists with a variety of complex metals in the form of secondary mineral phases in nature.
Zhang Yi   +7 more
core   +1 more source

Quantum cores of optical phase singularities [PDF]

open access: yes, 2004
The nodal line singularities (optical vortices) of classical scalar optics are smoothed in quantum optics, because of spontaneous emission into unoccupied modes. The radius of the 'quantum core' surrounding each classical singularity is proportional to ??
Dennis, MR   +5 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Spectral Singularities with Directional Sensitivity

open access: yes, 2020
We propose a class of spectral singularities that are sensitive to the direction of excitation and are arising in nonlinear systems with broken parity symmetry.
Hamidreza Ramezani (14236586)
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

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