Results 91 to 100 of about 181,239 (315)

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Range–Null Space Decomposition With Frequency-Oriented Mamba for Spectral Superresolution

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Spectral superresolution (SSR) is a technique aimed at reconstructing hyperspectral images (HSIs) from images with low spectral resolution. Previous methods combining mathematical models with deep learning have shown promising performance for HSI ...
Meimei Weng, Jianjun Liu, Jinlong Yang, Zebin Wu, Liang Xiao   +4 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Assessment of long-term structural movements in a historic cliffside construction through Lomb-Scargle spectral analysis of unevenly spaced time records: the Punta Begoña Galleries (Getxo, Spain) [PDF]

, 2022
Jesús A. Uriarte, R. Morales‐Juberias, Jon Ander Clemente, Iñaki Antigüedad, Tomás Morales   +4 more
openalex   +1 more source

The Accretion Disk Size Problem in AGN Disk Reverberation Mapping Is an Obscuration Effect: A Uniform AGN Sample Study with Swift

The Astrophysical Journal
In the past decade, Swift has performed several active galactic nucleus (AGN) high-cadence reverberation mapping campaigns, and it has generally found that the UV/optical interband lags are ∼3 times longer than predicted for a standard thin disk, thus ...
Collin Lewin, Erin Kara, Christos Panagiotou, Edward M. Cackett, Jonathan Gelbord, Juan V. Hernández Santisteban, Keith Horne, Gerard A. Kriss   +7 more
doaj   +1 more source

Hyperspectral Target Detection Based on Masked Autoencoder Data Augmentation

Remote Sensing
Deep metric learning combines deep learning with metric learning to explore the deep spectral space and distinguish between the target and background. Current target detection methods typically fail to accurately distinguish local differences between the
Zhixuan Zhuang, Jinhui Lan, Yiliang Zeng
doaj   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Use of spectral decomposition technique for delineation of channels at Solar gas discovery, offshore West Nile Delta, Egypt

Egyptian Journal of Petroleum, 2016
This paper presents a case study of spectral decomposition of seismic data and how it aids in seismic data interpretation. It is also known as time–frequency analysis where non-stationary signals in time/space are from time/space domain to time/space vs.
Adel A.A. Othman, M. Fathy, Ali Maher
doaj   +1 more source