Results 101 to 110 of about 947,207 (275)
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
AxiomsWe present a mathematical analysis of the sterol regulatory element-binding protein 2 (SREBP-2) pathway, a key regulator of intracellular cholesterol homeostasis.
Mostafa Bachar
doaj +1 more source
Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett +8 more
wiley +1 more source
On the continuity of the map square root of nonnegative isomorphisms in Hilbert spaces
Revista Integración, 2015 Let H be a real (or complex) Hilbert space. Every nonnegative operator L ∈ L(H) admits a unique nonnegative square root R ∈ L(H), i.e., a nonnegative operator R ∈ L(H) such that R2 = L.
Jeovanny de Jesus Muentes Acevedo
doaj
The Self-Adjoint Fractional Heun Operator and Its Spectral Properties
MathematicsThis paper introduces a rigorously defined fractional Heun operator constructed through a symmetric composition of left and right Riemann–Liouville fractional derivatives.
Muath Awadalla
doaj +1 more source
Arthritis Care &Research, EarlyView.Objective This study aims to develop hip morphology‐based radiographic hip osteoarthritis (RHOA) risk prediction models and investigates the added predictive value of hip morphology measurements and the generalizability to different populations. Methods We combined data from nine prospective cohort studies participating in the Worldwide Collaboration ...
Myrthe A. van den Berg +26 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective Recent inflammatory bowel disease (IBD) treatment guidelines have recommended against nonsteroidal anti‐inflammatory drug (NSAID) use despite prevalent musculoskeletal symptoms and opioid overuse in this population. Given the discordance between changing national guidelines and potential clinical utility, we sought to assess national temporal
Adam S. Mayer +5 more
wiley +1 more source
Existence of a principal eigenvalue for the Tricomi problem
Electronic Journal of Differential Equations, 2000 The existence of a principal eigenvalue is established for the Tricomi problem in normal domains; that is, the existence of a positive eigenvalue of minimum modulus with an associated positive eigenfunction.
Daniela Lupo, Kevin R. Payne
doaj
Arthritis Care &Research, Accepted Article.Objective Knee osteoarthritis (OA) commonly affects individuals with Type 2 diabetes (T2DM) and is associated with increased risk of diabetes‐related complications. To better understand potential mechanisms, we examined the association between symptomatic knee OA and glycemic control in individuals with T2DM.
Lauren K. King +10 more
wiley +1 more source
Immune Checkpoint Inhibitor Related Myositis and Associated Triad Overlap Syndrome
Arthritis Care &Research, Accepted Article.Objective Immune checkpoint inhibitor (ICI) myositis is a rare but highly morbid condition, particularly with the ICI myositis triad syndrome of myositis, myocarditis, and myasthenia gravis. We report the clinical characteristics of ICI myositis and all‐cause mortality in these patients.
Selene Rubino +9 more
wiley +1 more source