Results 81 to 90 of about 6,490,412 (293)

On the Holographic Spectral Effects of Time-Interval Subdivisions

open access: yesQuantum Reports
Drawing on formal parallels between scalar diffraction theory and quantum mechanics, it is demonstrated that quantum wavefunction propagation requires a holographic model of time.
Sky Nelson-Isaacs
doaj   +1 more source

Infinite-dimensional Lie Algebras, Representations, Hermitian Duality and the Operators of Stochastic Calculus

open access: yesAxioms, 2016
We study densely defined unbounded operators acting between different Hilbert spaces. For these, we introduce a notion of symmetric (closable) pairs of operators.
Palle Jorgensen, Feng Tian
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

An Abstract Linking Theorem Applied to Indefinite Problems Via Spectral Properties

open access: yesAdvanced Nonlinear Studies, 2019
An abstract linking result for Cerami sequences is proved without the Cerami condition. It is applied directly in order to prove the existence of critical points for a class of indefinite problems in infinite-dimensional Hilbert Spaces.
Maia Liliane A., Soares Mayra
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Spectral Characteristics of Biological Soil Crusts under the Different Types in the Water-Wind Erosion Crisscross Region on the Loess Plateau

open access: yes, 2018
The study on spectral characteristics of biological soil crust in the water-wind erosion crisscross region in the Loess Plateau has important scientific value for the identification of biological soil crust based on remote sensing technology at regional ...
Sun, WY (reprint author), Northwest A&F Univ, State Key Lab Soil Eros & Dryland Farming Loess P, Yangling 712100, Shaanxi, Peoples R China.   +7 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

An p theory of PCA and spectral clustering

open access: yes
Principal Component Analysis (PCA) is a powerful tool in statistics and machine learning. While existing study of PCA focuses on the recovery of principal components and their associated eigenvalues, there are few precise characterizations of individual ...
Wang, Kaizheng   +2 more
core   +1 more source

Spectral Matching through Data Compression [PDF]

open access: yes, 2011
This paper proposes to use compression-based similarity measures to cluster spectral signatures on the basis of their similarities. Such universal distances estimate the shared information between two objects by comparing their compression factors ...
Avbelj, Janja   +4 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

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