Results 101 to 110 of about 6,490,412 (293)
A spectral theory for Wright's inbreeding coefficients and related quantities. [PDF]
PLoS Genet, 2021 François O, Gain C.
europepmc +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Existence of a principal eigenvalue for the Tricomi problem
Electronic Journal of Differential Equations, 2000 The existence of a principal eigenvalue is established for the Tricomi problem in normal domains; that is, the existence of a positive eigenvalue of minimum modulus with an associated positive eigenfunction.
Daniela Lupo, Kevin R. Payne
doaj
On the Spectral Analysis of Diamond-α Sturm–Liouville Problems on Uniform Time Scales
AxiomsThis paper investigates a Sturm–Liouville problem formulated in terms of the diamond-α derivative on a uniform time scale. The proposed setting combines the delta and nabla components within a unified spectral framework.
Tuba Gulsen +2 more
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
proof of the discreteness of the bosonic membrane spectrum
Publicaciones en Ciencias y Tecnología, 2013 Using a spectral theorem for Schrodinger like equations, we present a proof of the discreteness of the spectrum for open bosonic membrane, considering L2 immersion maps from the 2 dimensional interval, at constant time, to at minkowski space.
doaj
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source