Results 71 to 80 of about 6,265,192 (292)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Spectral Matching through Data Compression [PDF]
, 2011 This paper proposes to use compression-based similarity measures to cluster spectral signatures on the basis of their similarities. Such universal distances estimate the shared information between two objects by comparing their compression factors ...
Avbelj, Janja +4 more
core
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
High Performance multivariable spectral estimator with Bounded McMillan Degree [PDF]
, 2010 Spectral estimation is a prominent issue with applications in a widespread variety of fields, from signal processing to biology. To the present, multivariable spectral estimation with complexity constraints on the acceptable solutions is a challenging ...
Masiero, Chiara
core
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
New Journal of Physics, 2018 Relaxation and first passage processes are the pillars of kinetics in condensed matter, polymeric and single-molecule systems. Yet, an explicit connection between relaxation and first passage time-scales so far remained elusive.
David Hartich, Aljaž Godec
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
SPECTRAL THEORY FOR STRUCTURED PERTURBATIONS OF LINEAR OPERATORS
, 2018 We characterize the spectrum (and its parts) of operators which can be represented as "G=A+BC" for a "simpler" operator A and a structured perturbation BC.
Adler, Martin, ENGEL, KLAUS JOCHEN OTTO
core +1 more source
Spectral Theory for the Transmission Eigenvalue Problem
, 2019 The transmission eigenvalue problem plays a central role in inverse scattering theory. This is a non-selfadjoint problem for a coupled pair of partial differential equations in a bounded domain corresponding to the support of the scattering object ...
Colton, David
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source