Results 51 to 60 of about 106,318 (262)

Spectral Theory For Strongly Continuous Cosine

open access: yesConcrete Operators, 2021
Let (C(t))t∈ℝ be a strongly continuous cosine family and A be its infinitesimal generator. In this work, we prove that, if C(t) – cosh λt is semi-Fredholm (resp.
Boua Hamid
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

A PROOF OF THE DISCRETENESS OF THE BOSONIC MEMBRANE SPECTRUM // UNA PRUEBA DE LA DISCRETITUD DEL ESPECTRO DE LA MEMBRANA BOSÓNICA ABIERTA

open access: yesPublicaciones en Ciencias y Tecnología, 2013
Using an spectral theorem for Schrödinger like equations, we present a proof of the discreteness of the spectrum for bosonic membrane in a .at minkowski space.
Rafael Torrealba Suárez
doaj  

Infinite-dimensional Lie Algebras, Representations, Hermitian Duality and the Operators of Stochastic Calculus

open access: yesAxioms, 2016
We study densely defined unbounded operators acting between different Hilbert spaces. For these, we introduce a notion of symmetric (closable) pairs of operators.
Palle Jorgensen, Feng Tian
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

An Abstract Linking Theorem Applied to Indefinite Problems Via Spectral Properties

open access: yesAdvanced Nonlinear Studies, 2019
An abstract linking result for Cerami sequences is proved without the Cerami condition. It is applied directly in order to prove the existence of critical points for a class of indefinite problems in infinite-dimensional Hilbert Spaces.
Maia Liliane A., Soares Mayra
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

An introduction to the distorted Fourier transform

open access: yesAdvanced Nonlinear Studies
This article is intended as an introduction to the distorted Fourier transform associated with a Schrödinger operator on the line or the half-line. This versatile tool has seen numerous applications in nonlinear PDE in recent years.
Ko Haram, Schlag Wilhelm
doaj   +1 more source

On the Holographic Spectral Effects of Time-Interval Subdivisions

open access: yesQuantum Reports
Drawing on formal parallels between scalar diffraction theory and quantum mechanics, it is demonstrated that quantum wavefunction propagation requires a holographic model of time.
Sky Nelson-Isaacs
doaj   +1 more source

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