Results 51 to 60 of about 947,207 (275)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Pseudospectra and eigenvalue asymptotics for disordered non-selfadjoint operators in the semiclassical limit

open access: yesFrontiers in Applied Mathematics and Statistics
The purpose of this note is to review certain recent results concerning the pseudospectra and the eigenvalues asymptotics of non-selfadjoint semiclassical pseudo-differential operators subject to small random perturbations.
Martin Vogel
doaj   +1 more source

Spectral Mixing Theory-Based Double-Branch Network for Spectral Super-Resolution

open access: yesRemote Sensing, 2023
Due to the limitations of imaging systems, the swath width of available hyperspectral images (HSIs) is relatively narrow, making it difficult to meet the demands of various applications.
Lingyu Sha   +4 more
doaj   +1 more source

Spectral Geometry and Causality

open access: yes, 1996
For a physical interpretation of a theory of quantum gravity, it is necessary to recover classical spacetime, at least approximately. However, quantum gravity may eventually provide classical spacetimes by giving spectral data similar to those appearing ...
Kopf, Tomas
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Characterization of constant sign Green's function for a two-point boundary-value problem by means of spectral theory

open access: yesElectronic Journal of Differential Equations, 2017
This article is devoted to the study of the parameter's set where the Green's function related to a general linear nth-order operator, depending on a real parameter, T_n[M], coupled with many different two point boundary value conditions, is of ...
Alberto Cabada, Lorena Saavedra
doaj  

Spectral Theory and Hardy Spaces for Bessel Operators in Non-Standard Geometries

open access: yesMathematics
This paper develops novel results in the harmonic analysis of Bessel operators, extending their theory to higher-dimensional and non-Euclidean spaces. We present a refined framework for Hardy spaces associated with Bessel operators, emphasizing atomic ...
Saeed Hashemi Sababe
doaj   +1 more source

Asymptotic spectral theory for nonlinear time series

open access: yes, 2007
We consider asymptotic problems in spectral analysis of stationary causal processes. Limiting distributions of periodograms and smoothed periodogram spectral density estimates are obtained and applications to the spectral domain bootstrap are given ...
Shao, Xiaofeng, Wu, Wei Biao
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Functional Determinants for Radially Separable Partial Differential Operators

open access: yesActa Polytechnica, 2007
Functional determinants of differential operators play a prominent role in many fields of theoretical and mathematical physics, ranging from condensed matter physics, to atomic, molecular and particle physics.
G. V. Dunne
doaj  

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