Results 91 to 100 of about 2,215,341 (299)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A Supervised Approach for Estimating Fractional Abundances of Binary Intimate Mixtures
IEEE Journal of Selected Topics in Applied Earth Observations and Remote SensingIn this work, we propose a supervised framework for spectral unmixing of binary intimate mixtures. The core idea is based on geodesic distance measurements and regression to estimate the fractional abundances.
Bikram Koirala +2 more
doaj +1 more source
Sound Visualization Demonstrates Velopharyngeal Coupling and Complex Spectral Variability in Asian Elephants. [PDF]
Animals (Basel), 2022 Beeck VC +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Using novel spectral-timing techniques to probe the rapid variability of X-Ray Binaries
, 2011 X-ray spectral variability is a powerful probe of the relationship between the accretion disc and corona in accreting compact objects. In this thesis, I present the use of variability techniques to disentangle the different variable components of X-ray ...
Wilkinson, Tony
core +1 more source
Current Directions in Biomedical Engineering, 2015 Heart Rate Variability studies are a known measure for the autonomous control of the heart rate. In special situations, its interpretation can be ambiguous, since the respiration has a major influence on the heart rate variability. For this reason it has
Kircher Michael +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
awesome-spectral-indices/spectral: 0.2.0
, 2022 Spectral v0.2.0 :artificial_satellite: :seedling: Improvements The Awesome Spectral Indices list was upgraded to v0.2 ...
David Montero Loaiza, actions-user
core +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source