Results 101 to 110 of about 2,215,341 (299)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Redshift dependence of QSO spectral variability

, 2006
We present a combined analysis of the optical spectral variability for two samples of QSOs, 42 objects at z < 0.4 monitored at the Wise Observatory, plus 59 objects up to z approximate to 3 in the field of the Magellanic Clouds, detected and/or monitored
Vagnetti, F, TREVESE, Dario, VAGNETTI, FAUSTO, VAGNETTI F, Trevese, D., Trevese, D   +5 more
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Spectral Learning of Latent-Variable PCFGs.

, 2012
We introduce a spectral learning algorithm for latent-variable PCFGs (Petrov et al., 2006). Under a separability (singular value) condition, we prove that the method provides consistent parameter estimates.
Cohen, Shay B., Stratos, Karl, Collins, Michael, Foster, Dean P., Ungar, Lyle   +4 more
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Correlated Temporal and Spectral Variability [PDF]

AIP Conference Proceedings, 2007
The variability of neutron star and black hole X‐ray sources has several dimensions, because of the roles played by different important time‐scales. The variations on time scales of hours, weeks, and months, ranging from 50% to orders of magnitude, arise out of changes in the flow in the disk.
openaire   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Investigating Abiotic Sources of Spectral Variability From Multitemporal Hyperspectral Airborne Acquisitions Over the French Guyana Canopy

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Classifiers trained on airborne hyperspectral imagery are proficient in identifying tree species in hyperdiverse tropical rainforests. However, spectral fluctuations, influenced by intrinsic and environmental factors, such as the heterogeneity of ...
Colin Prieur, Antony Laybros, Giovanni Frati, Daniel Schlapfer, Jocelyn Chanussot, Gregoire Vincent   +5 more
doaj   +1 more source

Spectral Variability in Seyfert Galaxies [PDF]

Symposium - International Astronomical Union, 1987
Recent observations of spectral variability in active galactic nuclei have established the connection between the broad emission-line and optical continuum flux changes. The inferred size of the broad-line region is at least an order of magnitude smaller than conventional estimates based on photoionization models, which leads to new conclusions about ...
openaire   +1 more source

Spectral Characteristics of Biological Soil Crusts under the Different Types in the Water-Wind Erosion Crisscross Region on the Loess Plateau

, 2018
The study on spectral characteristics of biological soil crust in the water-wind erosion crisscross region in the Loess Plateau has important scientific value for the identification of biological soil crust based on remote sensing technology at regional ...
Sun, WY (reprint author), Northwest A&F Univ, State Key Lab Soil Eros & Dryland Farming Loess P, Yangling 712100, Shaanxi, Peoples R China., Zhang Yue, Mu Xing-min, Tian Yuan-sheng, Sun Wen-yi, Sun, WY (reprint author), Chinese Acad Sci & Minist Water Resources, Inst Soil & Water Conservat, Yangling 712100, Shaanxi, Peoples R China., Zhao Guang-ju, Gao Peng   +7 more
core   +1 more source