Results 121 to 130 of about 153,264 (305)
Using novel spectral-timing techniques to probe the rapid variability of X-Ray Binaries [PDF]
, 2011 X-ray spectral variability is a powerful probe of the relationship between the accretion disc and corona in accreting compact objects. In this thesis, I present the use of variability techniques to disentangle the different variable components of X-ray ...
Wilkinson, Tony
core
Correlated Temporal and Spectral Variability [PDF]
AIP Conference Proceedings, 2007 The variability of neutron star and black hole X‐ray sources has several dimensions, because of the roles played by different important time‐scales. The variations on time scales of hours, weeks, and months, ranging from 50% to orders of magnitude, arise out of changes in the flow in the disk.
openaire +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Quasar spectral variability from the XMM-Newton serendipitous source catalogue [PDF]
, 2016 Context. X-ray spectral variability analyses of active galactic nuclei (AGN) with moderate luminosities and redshifts typically show a softer when brighter behaviour.
R. Middei +15 more
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Quasar spectral slope variability in the optical band [PDF]
, 2002 We performed a new analysis of B and R light curves of a sample of PG quasars. We confirm the variability-redshift correlation and its explanation in terms of spectral variability, coupled with the increase of rest-frame observing frequency for quasars ...
Vagnetti, F +2 more
core +1 more source
A Measure of Variability in Comovement for Economic Variables : a Time-Varying Coherence Function Approach [PDF]
In this paper, we test the instability of comovement, in time and frequency domain, for the GDP growth rate of the US and the UK. We use the frequency approach, which is based on evolutionary spectral analysis (Priestley, 1965-1996).
Mohamed Boutahar, Essahbi Essaadi
core +3 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source