Results 141 to 150 of about 2,215,341 (299)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Spectral Timing Evolution of the Black Hole X-Ray Binary LMC X-3: An XPoSat View

open access: yesThe Astrophysical Journal
LMC X-3 is a persistent black hole high-mass X-ray binary and serves as an important laboratory for studying accretion disk evolution across different spectral states.
Sayantan Bhattacharya   +2 more
doaj   +1 more source

Complex X-Ray Spectral Variability in Mini-BAL QSOs

open access: yes, 2009
Multiple XMM–Newton observations of the mini-BAL QSOs PG 1351+640 and PG 1126–041 revealed dramatic and complex spectral variability on different timescales, providing clues about the physical mechanism responsible for outflows in quasars.
Massimo Cappi   +5 more
core   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

open access: yesFEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Are Multiwavelength Variability Events in Blazars Driven by a Common Stochastic Process?

open access: yesThe Astrophysical Journal
We investigate the underlying stochastic processes driving the multiwavelength variability of the blazar BL Lacertae over the past two decades. Observations from Weihai Observatory over 224 nights reveal that the power spectral slopes of intra-night ...
Jingran Xu   +3 more
doaj   +1 more source

SVHAE: Spectral Variability-Aware Hybrid Autoencoder for Hyperspectral Underwater Target Detection

open access: yesIEEE Access
Hyperspectral imaging (HSI) has evolved as an important tool for many applications, including remote sensing, crime investigation, target detection, disease diagnosis, and anomaly detection.
Suresh Aala   +6 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

open access: yesFEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow   +12 more
wiley   +1 more source

Spectral Variability of Quasar SDSS J030639.57+000343.1

open access: yes, 2014
In a sample of 60 quasars selected from the Sloan Digital Sky Survey (SDSS) with at least six-epoch spectroscopy, we investigated the variability of emission lines and continuum luminosity.
Gu, Minfeng, Guo, Hengxiao
core  

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

open access: yesFEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty   +13 more
wiley   +1 more source

Improving High-Frequency Spectral Estimates in Spectral Ratio Analysis Using Between-Event PGA Differences

open access: yesThe Seismic Record
Assessment of ground-motion variability is crucial for seismic hazard analysis. However, the variability of peak ground accelerations (PGAs) and spectral stress drops has long been inconsistent, partly due to limitations of the single-corner-frequency ...
Shota Shimmoto
doaj   +1 more source

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