Results 131 to 140 of about 153,264 (305)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Investigating Abiotic Sources of Spectral Variability From Multitemporal Hyperspectral Airborne Acquisitions Over the French Guyana Canopy

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Classifiers trained on airborne hyperspectral imagery are proficient in identifying tree species in hyperdiverse tropical rainforests. However, spectral fluctuations, influenced by intrinsic and environmental factors, such as the heterogeneity of ...
Colin Prieur, Antony Laybros, Giovanni Frati, Daniel Schlapfer, Jocelyn Chanussot, Gregoire Vincent   +5 more
doaj   +1 more source

Spectral Learning of Latent-Variable PCFGs.

, 2012
We introduce a spectral learning algorithm for latent-variable PCFGs (Petrov et al., 2006). Under a separability (singular value) condition, we prove that the method provides consistent parameter estimates.
Cohen, Shay B., Stratos, Karl, Collins, Michael, Foster, Dean P., Ungar, Lyle   +4 more
openaire   +2 more sources

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

The Relation between Simulated Multiwavelength Blazar Variability and Stochastic Fluctuations

The Astrophysical Journal
Blazars exhibit multiwavelength variability, a phenomenon whose underlying mechanisms remain elusive. This study investigates the origin of such variability through leptonic blazar emission simulations, focusing on stochastic fluctuations in ...
Hannes Thiersen, Michael Zacharias, Markus Böttcher   +2 more
doaj   +1 more source

Advancements in solar spectral irradiance measurements by the TSIS-1 spectral irradiance monitor and its role for long-term data continuity

Journal of Space Weather and Space Climate
The first implementation of NASA’s Total and Spectral Solar Irradiance Sensor (TSIS-1) launched on December 15th, 2017, and was integrated into the International Space Station (ISS) to measure both the total solar irradiance (TSI) and the solar spectral ...
Richard Erik, Coddington Odele, Harber Dave, Chambliss Michael, Penton Steven, Brooks Keira, Charbonneau Luke, Peck Courtney, Béland Stéphane, Pilewskie Peter, Woods Tom   +10 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spectral Variability of Supergiant HD21389

, 2022
Late B- and early A-type supergiants are interesting evolved stars exhibiting photometric variability accompanied by spectral changes. Particularly interesting is a group of pulsating stars named after Deneb as α Cyg variables. Deneb-type variables are known for decades to show variability in both brightness and radial velocities. Despite this group of
Pivoňková, K., Maryeva, O. (Olga), Aret, A., Checha, V.   +3 more
openaire   +1 more source