Results 261 to 270 of about 544,006 (376)

Detection and Behaviors of TEMPO Derivatives in Seven Mass Spectrometry Ionization Methods. [PDF]

J Mass Spectrom
Oyama KI, Hor S, Tsukamoto M, Zhang H.
europepmc   +1 more source

Bioorthogonal Postlabeling Reveals Nuclear Localization of a Highly Cytotoxic Half‐Sandwich Ir(III) Tetrazine Complex in Live Cells

ChemBioChem, EarlyView.
This study reports the synthesis of five tetrazine‐coordinated, half‐sandwich iridium complexes and extensively describe their reactivity. Live cell fluorescent bioorthogonal labeling reveals the nuclear tropism of the most cytotoxic complex. Intracellular imaging of anticancer metallodrugs often relies on prelabeling with organic fluorophores, which ...
Alfonso Annunziata, Sadek Amhaz, Jérémy Forté, Geoffrey Gontard, Romain Morichon, Joëlle Sobczak‐Thépot, Michèle Salmain   +6 more
wiley   +1 more source

The Role of Nanobubbles in Protein Unfolding during Electrothermal Supercharging. [PDF]

J Am Soc Mass Spectrom
Joseph G, Binny B, Venter AR.
europepmc   +1 more source

Boron‐Based Functionalities Enhance the Potency of 2,5‐Dimethylfuran‐Based IDO1 Inhibitors

ChemBioChem, EarlyView.
Indoleamine‐2,3‐dioxygenase‐1 (IDO1), a key immunoregulatory enzyme, is inhibited by novel boron derivatives (closo‐1,2‐ and 1,7‐carborane, boronic acids and esters, and benzoxaboroles) of 2,5‐dimethylfuran, each displaying low μM affinity for the human recombinant enzyme.
Thomas J. C. Carraro, Samrat Dasgupta, Jacqueline Ku, Shane R. Thomas, Louis M. Rendina   +4 more
wiley   +1 more source

Metabolomics Profiling and Advanced Methodologies for Wheat Stress Research. [PDF]

Metabolites
Liu Z, You J, Zhao P, Wang X, Sun S, Wang X, Gu S, Xu Q.   +7 more
europepmc   +1 more source

PCFT‐Independent Cellular Uptake of Cyclic Cell‐Penetrating Peptide‐Conjugated Folic Acid

ChemBioChem, EarlyView.
Cell‐penetrating peptide (CPP)‐conjugated folic acid mediates efficient internalization of folic acid that is independent of the presence of proton‐coupled folate transporter (PCFT) on the intestinal cells. CPP‐conjugated folic acid demonstrates superior cellular uptake at all studied pH and in the presence of PCFT inhibitors and shows enhanced ...
Vineet Kumar Mishra, Rheal Towner, Juan Carlos Rodriguez‐Lecompte, Marya Ahmed   +3 more
wiley   +1 more source

Multidimensional-Constrained Suspect Screening of Hydrophobic Contaminants Using Gas Chromatography-Atmospheric Pressure Chemical Ionization-Ion Mobility-Mass Spectrometry. [PDF]

Anal Chem
Shi X, Sobek A, Benskin JP.
europepmc   +1 more source

A de novo designed metalloprotein displays variable thermal stability and binding stoichiometry with transition metal ions

ChemBioChem, Accepted Article.
Metal‐binding selectivity in natural proteins is determined by multiple factors such as the protein’s structure, metal concentration within cellular compartments and the presence of metallochaperones. The in vitro selectivity of proteins for transition metal ions is largely governed by the Irving‐Williams series, that states protein‐metal complex ...
Britt Rooijakkers, Gaya Verhagen, Anneloes Cramer-Blok, Ed Zuidinga, Aimee Lynn Boyle   +4 more
wiley   +1 more source

Rapid detection of Tulipalin A with SESI-Orbitrap MS: an exploration across spring flowers. [PDF]

Plant Methods
Phan ANT, Eerlings R, Mengers HG, Blank LM.   +3 more
europepmc   +1 more source

Harnessing Organometallic Au(III) Complexes as Precision Scaffolds for Next‐Generation Therapeutic and Imaging Agents

ChemBioChem, EarlyView.
Cyclometalated gold(III) complexes offer a versatile platform for selective biological interactions, including cysteine arylation, redox modulation, and enzyme inhibition. This review explores their roles in anticancer, antimicrobial, and protein modification strategies, highlighting their ability to disrupt metabolic pathways, modulate aquaporins, and
Sophie R. Thomas, Riccardo Bonsignore
wiley   +1 more source