Results 51 to 60 of about 629,504 (222)
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Metabolomics by Gas Chromatography–Mass Spectrometry: Combined Targeted and Untargeted Profiling
Current Protocols in Molecular Biology, 2016 Gas chromatography–mass spectrometry (GC‐MS)–based metabolomics is ideal for identifying and quantitating small‐molecule metabolites (
O. Fiehn
semanticscholar +1 more source
Cluster SIMS Microscope Mode Mass Spectrometry Imaging [PDF]
arXiv, 2013 Microscope mode imaging for secondary ion mass spectrometry is a technique with the promise of simultaneous high spatial resolution and high speed imaging of biomolecules from complex surfaces. Technological developments such as new position-sensitive detectors, in combination with polyatomic primary ion sources, are required to exploit the full ...
arxiv
XLMOD: Cross-linking and chromatography derivatization reagents ontology [PDF]
arXiv, 2020 Mass spectrometry has experienced a rapid development since its first application for protein analysis in the 1980s. While the most common use of mass spectrometry for protein analysis is identification and quantification workflows on peptides (digested from their parent protein), there is also a rapidly growing use of mass spectrometry for structural ...
arxiv
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Nature Communications, 2016 Although mutations may represent attractive targets for immunotherapy, direct identification of mutated peptide ligands isolated from human leucocyte antigens (HLA) on the surface of native tumour tissue has so far not been successful.
M. Bassani-Sternberg +18 more
semanticscholar +1 more source
HIGH RESOLUTION MASS SPECTROMETRY IN LIPIDOMICS
Mass spectrometry reviews (Print), 2020 The boost of research output in lipidomics during the last decade is tightly linked to improved instrumentation in mass spectrometry. Associated with this trend is the shift from low resolution—toward high‐resolution lipidomics platforms.
Thomas Züllig, H. Köfeler
semanticscholar +1 more source
Mass Spectrometry and Tandem Mass Spectrometry: An Overview [PDF]
, 2014 In this chapter, a brief overview of fundamentals in mass spectrometry and of its applications in homeland security, forensic sciences and explosive detection, are presented.
openaire +3 more sources
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
A Cyclic Ion Mobility-Mass Spectrometry System.
Analytical Chemistry, 2019 Improvements in the performance and availability of commercial instrumentation have made ion mobility-mass spectrometry (IM-MS) an increasingly popular approach for the structural analysis of ionic species as well as for separation of complex mixtures ...
K. Giles +6 more
semanticscholar +1 more source